Acyl-protein thioesterase 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt O75608. Use UniProt O75608 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O75608 as the stable identity anchor, then attach disease evidence before program review.
Acyl-protein thioesterase 1
Review this target as Acyl-protein thioesterase 1, mapped to UniProt O75608. Sequence length is 230 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Acyl-protein thioesterase 1 as ChEMBL target CHEMBL1681631, mapped to UniProt O75608. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Acyl-protein thioesterase 1 is the right protein anchor across sources, using UniProt O75608 as the stable mapping.
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| Preferred Name | Acyl-protein thioesterase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O75608 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Acyl-protein thioesterase 1 |
| UniProt Accession | O75608 |
| Component Type | Protein |
| Sequence Length | 230 aa |
Acyl-protein thioesterase 1
Review this target as Acyl-protein thioesterase 1, mapped to UniProt O75608. Sequence length is 230 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5653589 | 9.33 | Kd | 0.466 | Preclinical |
| CHEMBL3133031 | 8.6 | IC50 | 2.5 | Preclinical |
| CHEMBL5568560 | 8.6 | IC50 | 2.5 | Preclinical |
| CHEMBL5565391 | 8.36 | IC50 | 4.4 | Preclinical |
| CHEMBL1673415 | 8.27 | IC50 | 5.4 | Preclinical |
| CHEMBL5562679 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL5565657 | 7.97 | IC50 | 10.6 | Preclinical |
| CHEMBL1903566 | 7.77 | IC50 | 17.0 | Preclinical |
| CHEMBL3133034 | 7.57 | IC50 | 27.0 | Preclinical |
| CHEMBL3133035 | 6.83 | IC50 | 148.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 12 | 12 | 7.6 |
| cell-based format | 2 | 0 | — |