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Target Snapshot

CHEMBL1697671 Target Snapshot

Placenta growth factor · SINGLE PROTEIN · Homo sapiens

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44Compounds
7Assays
0Approved Drugs
54.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Placenta growth factor shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P49763. Start with neoplasm, then reuse UniProt P49763 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with neoplasm, then reuse UniProt P49763 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 2 linked drugs
Open source guide
Disease program
neoplasm

Placenta growth factor shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.

Start review with neoplasm because it currently carries approved-linked support. Linked drugs include AFLIBERCEPT, TB-403. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 2 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Placenta growth factor as ChEMBL target CHEMBL1697671, mapped to UniProt P49763. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Placenta growth factor
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1697671
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P49763
Placenta growth factor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Placenta growth factor is the right protein anchor across sources, using UniProt P49763 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NamePlacenta growth factor
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP49763
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPlacenta growth factor
UniProt AccessionP49763
Component TypeProtein
Sequence Length221 aa

Placenta growth factor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Placenta growth factor, mapped to UniProt P49763. Sequence length is 221 aa.

Mapped IDP49763
Review namePlacenta growth factor
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Placenta growth factor shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
neoplasm
2 linked drugs · 2 direct · 2 efficacy
Linked drugAFLIBERCEPT
Linked drugTB-403
Approved-linked Approved
pathological myopia
2 linked drugs · 2 direct · 2 efficacy
Linked drugAFLIBERCEPT
Linked drugCONBERCEPT
Approved-linked Approved
retinal vein occlusion
2 linked drugs · 2 direct · 2 efficacy
Linked drugAFLIBERCEPT
Linked drugCONBERCEPT
Approved-linked Approved
wet macular degeneration
2 linked drugs · 2 direct · 2 efficacy
Linked drugAFLIBERCEPT
Linked drugCONBERCEPT
Approved-linked Approved
cancer
1 linked drug · 1 direct · 1 efficacy
Linked drugAFLIBERCEPT
Approved-linked Approved
colorectal adenocarcinoma
1 linked drug · 1 direct · 1 efficacy
Linked drugAFLIBERCEPT
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with neoplasm because it currently carries approved-linked support. Linked drugs include AFLIBERCEPT, TB-403. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseneoplasm
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Assay Mix

Activity Type Distribution

IC5023.0
KD31.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1689483 10.0 Kd 0.1 Preclinical
CHEMBL1689479 9.52 Kd 0.3 Preclinical
CHEMBL1689481 9.52 Kd 0.3 Preclinical
CHEMBL1689483 9.4 IC50 0.4 Preclinical
CHEMBL1689481 9.0 IC50 1.0 Preclinical
CHEMBL1689460 8.7 IC50 2.0 Preclinical
CHEMBL1689482 8.52 IC50 3.0 Preclinical
CHEMBL1689460 8.4 Kd 4.0 Preclinical
CHEMBL1689463 8.4 IC50 4.0 Preclinical
CHEMBL1689466 8.4 Kd 4.0 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
0
5.5
7
6.0
2
6.5
1
7.0
2
7.5
11
8.0
2
8.5
2
9.0
2
9.5
pChEMBL
Assay Landscape

Assay Landscape

7
Total Assays
30
Tested Compounds
1
Assay Types
Binding — 7 assays, 30 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 7 30 7.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine