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Target Snapshot

CHEMBL1741220 Target Snapshot

Bromodomain adjacent to zinc finger domain protein 2B · SINGLE PROTEIN · Homo sapiens

55,761Compounds
129Assays
0Approved Drugs
194.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9UIF8. Use UniProt Q9UIF8 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9UIF8 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Bromodomain adjacent to zinc finger domain protein 2B as ChEMBL target CHEMBL1741220, mapped to UniProt Q9UIF8. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Bromodomain adjacent to zinc finger domain protein 2B
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1741220
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9UIF8
Bromodomain adjacent to zinc finger domain protein 2B
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Bromodomain adjacent to zinc finger domain protein 2B is the right protein anchor across sources, using UniProt Q9UIF8 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBromodomain adjacent to zinc finger domain protein 2B
UniProt AccessionQ9UIF8
Component TypeProtein
Sequence Length2168 aa

Bromodomain adjacent to zinc finger domain protein 2B

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Bromodomain adjacent to zinc finger domain protein 2B, mapped to UniProt Q9UIF8. Sequence length is 2168 aa.

Mapped IDQ9UIF8
Review nameBromodomain adjacent to zinc finger domain protein 2B
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC50121.0
KI5.0
EC501.0
KD67.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3739699 7.22 Kd 60.0 Preclinical
CHEMBL4296718 6.77 Kd 170.0 Preclinical
CHEMBL4296718 6.76 IC50 174.0 Preclinical
CHEMBL5274024 6.72 Kd 190.0 Preclinical
CHEMBL3739699 6.44 IC50 360.0 Preclinical
CHEMBL3771216 6.43 IC50 370.0 Preclinical
CHEMBL3774575 6.4 Kd 400.0 Preclinical
CHEMBL5715923 6.4 Kd 400.0 Preclinical
CHEMBL3770155 6.39 IC50 410.0 Preclinical
CHEMBL3770449 6.27 IC50 540.0 Preclinical
Distribution

pChEMBL Value Distribution

20
5.0
18
5.5
27
6.0
8
6.5
4
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

129
Total Assays
92
Tested Compounds
2
Assay Types
Binding — 127 assays, 92 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 59 61 5.1
single protein format 53 25 5.8
cell-based format 15 6 5.2
Functional — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine