Cysteine protease ATG4B · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9Y4P1. Use UniProt Q9Y4P1 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9Y4P1 as the stable identity anchor, then attach disease evidence before program review.
Cysteine protease ATG4B
Review this target as Cysteine protease ATG4B, mapped to UniProt Q9Y4P1. Sequence length is 393 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cysteine protease ATG4B as ChEMBL target CHEMBL1741221, mapped to UniProt Q9Y4P1. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cysteine protease ATG4B |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y4P1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cysteine protease ATG4B |
| UniProt Accession | Q9Y4P1 |
| Component Type | Protein |
| Sequence Length | 393 aa |
Cysteine protease ATG4B
Review this target as Cysteine protease ATG4B, mapped to UniProt Q9Y4P1. Sequence length is 393 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4581663 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL4546760 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL4520267 | 7.14 | IC50 | 73.0 | Preclinical |
| CHEMBL4520585 | 6.89 | IC50 | 130.0 | Preclinical |
| CHEMBL51085 | 6.75 | IC50 | 180.0 | Clinical |
| CHEMBL4553669 | 6.72 | IC50 | 190.0 | Preclinical |
| CHEMBL4567870 | 6.57 | IC50 | 270.0 | Preclinical |
| CHEMBL1496397 | 6.5 | IC50 | 316.0 | Preclinical |
| CHEMBL4469737 | 6.44 | IC50 | 360.0 | Preclinical |
| CHEMBL1391013 | 6.4 | IC50 | 399.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 28 | 84 | 5.4 |
| assay format | 16 | 5 | 5.5 |
| cell-based format | 16 | 40 | 5.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 325 | 5.0 |