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Target Snapshot

CHEMBL1743122 Target Snapshot

Solute carrier family 22 member 2 · SINGLE PROTEIN · Homo sapiens

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179Compounds
93Assays
40Approved Drugs
162.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt O15244. Use UniProt O15244 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O15244 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Solute carrier family 22 member 2 as ChEMBL target CHEMBL1743122, mapped to UniProt O15244. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Solute carrier family 22 member 2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1743122
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O15244
Solute carrier family 22 member 2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Solute carrier family 22 member 2 is the right protein anchor across sources, using UniProt O15244 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSolute carrier family 22 member 2
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtO15244
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSolute carrier family 22 member 2
UniProt AccessionO15244
Component TypeProtein
Sequence Length555 aa

Solute carrier family 22 member 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Solute carrier family 22 member 2, mapped to UniProt O15244. Sequence length is 555 aa.

Mapped IDO15244
Review nameSolute carrier family 22 member 2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

40
Approved
6
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC50149.0
KI13.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5864617 7.38 IC50 42.0 Preclinical
CHEMBL5995971 7.38 IC50 42.0 Preclinical
CHEMBL5870848 7.03 IC50 94.0 Preclinical
CHEMBL2074900 7.0 IC50 100.0 Preclinical
CHEMBL1197556 7.0 Ki 100.0 Preclinical
CHEMBL5962549 6.86 IC50 137.0 Preclinical
CHEMBL6000266 6.86 IC50 137.0 Preclinical
CHEMBL6056512 6.86 IC50 137.0 Preclinical
CHEMBL5830493 6.69 IC50 204.0 Preclinical
CHEMBL6049097 6.69 IC50 204.0 Preclinical
Distribution

pChEMBL Value Distribution

39
5.0
26
5.5
20
6.0
13
6.5
8
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

BICTEGRAVIR
CHEMBL3989866
Approved 2018
Properties Compare Identifier
TACRINE
CHEMBL95
Approved 1993
Properties Compare Identifier
ONDANSETRON
CHEMBL46
Approved 1991
Properties Compare Identifier
CHLORHEXIDINE
CHEMBL790
Approved 1976
Properties Compare Identifier
IMIPRAMINE
CHEMBL11
Approved 1959
Properties Compare Identifier
Assay Landscape

Assay Landscape

94
Total Assays
106
Tested Compounds
3
Assay Types
Functional — 62 assays, 23 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 62 23 5.3
ADME — 19 assays, 8 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 10 8 5.7
single protein format 9 0 —
Binding — 13 assays, 106 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 7 83 5.4
single protein format 5 0 —
assay format 1 23 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine