Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL1777 Target Snapshot

Cytochrome b · SINGLE PROTEIN · Plasmodium falciparum

0Compounds
0Assays
0Approved Drugs
0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Cytochrome b shows approved-linked disease relevance led by amebiasis. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q02768. Start with amebiasis, then reuse UniProt Q02768 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with amebiasis, then reuse UniProt Q02768 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
amebiasis

Cytochrome b shows approved-linked disease relevance led by amebiasis. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with amebiasis because it currently carries approved-linked support. Linked drugs include ATOVAQUONE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cytochrome b as ChEMBL target CHEMBL1777, mapped to UniProt Q02768. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cytochrome b
SINGLE PROTEIN · Plasmodium falciparum
As of 2026-09-14
ChEMBL target ID
CHEMBL1777
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q02768
Cytochrome b
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cytochrome b is the right protein anchor across sources, using UniProt Q02768 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why amebiasis is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCytochrome b
UniProt AccessionQ02768
Component TypeProtein
Sequence Length376 aa

Cytochrome b

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Cytochrome b, mapped to UniProt Q02768. Sequence length is 376 aa.

Mapped IDQ02768
Review nameCytochrome b
OrganismPlasmodium falciparum
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Cytochrome b shows approved-linked disease relevance led by amebiasis. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
amebiasis
1 linked drug · 1 direct · 1 efficacy
Linked drugATOVAQUONE
Approved-linked Approved
malaria
1 linked drug · 1 direct · 1 efficacy
Linked drugATOVAQUONE
Approved-linked Approved
pneumocystosis
1 linked drug · 1 direct · 1 efficacy
Linked drugATOVAQUONE
Approved-linked Approved
pneumocystosis
1 linked drug · 1 direct · 1 efficacy
Linked drugATOVAQUONE
Late clinical Phase III
Plasmodium falciparum malaria
1 linked drug · 1 direct · 1 efficacy
Linked drugATOVAQUONE
Clinical signal Phase II
cerebral toxoplasmosis
1 linked drug · 1 direct · 1 efficacy
Linked drugATOVAQUONE
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with amebiasis because it currently carries approved-linked support. Linked drugs include ATOVAQUONE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseamebiasis
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Source · ChEMBL 36 via Core Engine