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Target Snapshot

CHEMBL1777665 Target Snapshot

Solute carrier family 22 member 6 · SINGLE PROTEIN · Rattus norvegicus

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117Compounds
105Assays
14Approved Drugs
63.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt O35956. Use UniProt O35956 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O35956 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Solute carrier family 22 member 6 as ChEMBL target CHEMBL1777665, mapped to UniProt O35956. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Solute carrier family 22 member 6
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL1777665
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O35956
Solute carrier family 22 member 6
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Solute carrier family 22 member 6 is the right protein anchor across sources, using UniProt O35956 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSolute carrier family 22 member 6
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtO35956
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSolute carrier family 22 member 6
UniProt AccessionO35956
Component TypeProtein
Sequence Length551 aa

Solute carrier family 22 member 6

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Solute carrier family 22 member 6, mapped to UniProt O35956. Sequence length is 551 aa.

Mapped IDO35956
Review nameSolute carrier family 22 member 6
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

14
Approved
1
Phase I
Assay Mix

Activity Type Distribution

IC5010.0
KI53.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2075007 6.4 Ki 400.0 Preclinical
CHEMBL571 6.3 IC50 500.0 Approved
CHEMBL2075010 5.96 Ki 1100.0 Preclinical
CHEMBL472 5.8 Ki 1600.0 Approved
CHEMBL2074738 5.72 Ki 1900.0 Preclinical
CHEMBL154 5.7 Ki 2000.0 Approved
CHEMBL2074600 5.56 Ki 2740.0 Preclinical
CHEMBL521 5.46 Ki 3500.0 Approved
CHEMBL6 5.38 Ki 4200.0 Approved
CHEMBL1072 5.26 Ki 5500.0 Approved
Distribution

pChEMBL Value Distribution

8
5.0
5
5.5
2
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

KETOPROFEN
CHEMBL571
Approved 1986
Properties Compare Identifier
Assay Landscape

Assay Landscape

107
Total Assays
40
Tested Compounds
2
Assay Types
Functional — 105 assays, 40 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 103 40 5.2
organism-based format 2 0 —
Binding — 2 assays, 7 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 7 4.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine