DNA topoisomerase 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13DNA topoisomerase 1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 17 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P11387. Start with neoplasm, then reuse UniProt P11387 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt P11387 as the stable protein anchor across project notes and exports.
DNA topoisomerase 1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 17 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include 7-ETHYL-10-HYDROXYCAMPTOTHECIN, AR-67, BECATECARIN, BELOTECAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyDNA topoisomerase 1
Review this target as DNA topoisomerase 1, mapped to UniProt P11387. Sequence length is 765 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats DNA topoisomerase 1 as ChEMBL target CHEMBL1781, mapped to UniProt P11387. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether DNA topoisomerase 1 is the right protein anchor across sources, using UniProt P11387 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 17 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | DNA topoisomerase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P11387 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA topoisomerase 1 |
| UniProt Accession | P11387 |
| Component Type | Protein |
| Sequence Length | 765 aa |
DNA topoisomerase 1
Review this target as DNA topoisomerase 1, mapped to UniProt P11387. Sequence length is 765 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
DNA topoisomerase 1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include 7-ETHYL-10-HYDROXYCAMPTOTHECIN, AR-67, BECATECARIN, BELOTECAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1813808 | 9.53 | Kd | 0.296 | Preclinical |
| CHEMBL1813809 | 8.58 | Kd | 2.65 | Preclinical |
| CHEMBL474561 | 8.48 | EC50 | 3.3 | Preclinical |
| CHEMBL5653589 | 8.19 | Kd | 6.526 | Preclinical |
| CHEMBL135492 | 8.1 | EC50 | 8.0 | Preclinical |
| CHEMBL338843 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL507686 | 7.92 | EC50 | 12.0 | Preclinical |
| CHEMBL335455 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL503051 | 7.8 | EC50 | 16.0 | Preclinical |
| CHEMBL133209 | 7.77 | EC50 | 17.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 945 | 362 | 5.7 |
| cell-based format | 138 | 86 | 5.9 |
| assay format | 46 | 16 | 4.3 |
| subcellular format | 2 | 0 | — |
| tissue-based format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 38 | 45 | 6.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 0 | — |