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Target Snapshot

CHEMBL1781862 Target Snapshot

Calmodulin-domain protein kinase 1 · SINGLE PROTEIN · Toxoplasma gondii

472Compounds
14Assays
1Approved Drugs
881.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9BJF5. Use UniProt Q9BJF5 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9BJF5 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Protein anchor
non-specific serine/threonine protein kinase

non-specific serine/threonine protein kinase

Review this target as Calmodulin-domain protein kinase 1, mapped to UniProt Q9BJF5. ChEMBL maps the protein component as non-specific serine/threonine protein kinase. Sequence length is 507 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt Q9BJF5 Protein 507 aa
Open protein block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Calmodulin-domain protein kinase 1 as ChEMBL target CHEMBL1781862, mapped to UniProt Q9BJF5. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Calmodulin-domain protein kinase 1
SINGLE PROTEIN · Toxoplasma gondii
As of 2026-09-14
ChEMBL target ID
CHEMBL1781862
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9BJF5
non-specific serine/threonine protein kinase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Labelnon-specific serine/threonine protein kinase
UniProt AccessionQ9BJF5
Component TypeProtein
Sequence Length507 aa

non-specific serine/threonine protein kinase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Calmodulin-domain protein kinase 1, mapped to UniProt Q9BJF5. ChEMBL maps the protein component as non-specific serine/threonine protein kinase. Sequence length is 507 aa.

Mapped IDQ9BJF5
Review nameCalmodulin-domain protein kinase 1
OrganismToxoplasma gondii
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC50879.0
EC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2079167 9.22 IC50 0.6 Preclinical
CHEMBL2079170 9.15 IC50 0.7 Preclinical
CHEMBL2079317 9.15 IC50 0.7 Preclinical
CHEMBL5853465 9.15 IC50 0.7 Preclinical
CHEMBL5926676 9.15 IC50 0.7 Preclinical
CHEMBL2078865 9.1 IC50 0.8 Preclinical
CHEMBL4591429 9.1 IC50 0.8 Preclinical
CHEMBL2079232 9.05 IC50 0.9 Preclinical
CHEMBL4553699 9.05 IC50 0.9 Preclinical
CHEMBL4571877 9.0 IC50 1.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
31
5.5
61
6.0
82
6.5
146
7.0
221
7.5
221
8.0
78
8.5
19
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MEBENDAZOLE
CHEMBL685
Approved 1974
Assay Landscape

Assay Landscape

14
Total Assays
508
Tested Compounds
1
Assay Types
Binding — 14 assays, 508 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 12 432 7.7
assay format 1 28 7.5
cell-free format 1 48 7.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine