Endoplasmic reticulum chaperone BiP · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P11021. Use UniProt P11021 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P11021 as the stable identity anchor, then attach disease evidence before program review.
Endoplasmic reticulum chaperone BiP
Review this target as Endoplasmic reticulum chaperone BiP, mapped to UniProt P11021. Sequence length is 654 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Endoplasmic reticulum chaperone BiP as ChEMBL target CHEMBL1781865, mapped to UniProt P11021. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Endoplasmic reticulum chaperone BiP |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P11021 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Endoplasmic reticulum chaperone BiP |
| UniProt Accession | P11021 |
| Component Type | Protein |
| Sequence Length | 654 aa |
Endoplasmic reticulum chaperone BiP
Review this target as Endoplasmic reticulum chaperone BiP, mapped to UniProt P11021. Sequence length is 654 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5653589 | 7.62 | Kd | 23.8 | Preclinical |
| CHEMBL1232461 | 7.25 | Kd | 56.0 | Clinical |
| CHEMBL462871 | 7.22 | Kd | 60.0 | Preclinical |
| CHEMBL470334 | 7.1 | Kd | 80.0 | Preclinical |
| CHEMBL5414287 | 6.96 | Kd | 110.0 | Preclinical |
| CHEMBL1232461 | 6.89 | IC50 | 130.0 | Clinical |
| CHEMBL515570 | 6.64 | Kd | 230.0 | Preclinical |
| CHEMBL473972 | 6.6 | Kd | 250.0 | Preclinical |
| CHEMBL3576921 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL5431926 | 6.48 | Kd | 334.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 24 | 37 | 5.8 |
| cell-based format | 12 | 13 | 4.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 0 | — |