Amiloride-sensitive sodium channel subunit alpha · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P37088. Use UniProt P37088 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P37088 as the stable identity anchor, then attach disease evidence before program review.
Epithelial sodium channel subunit alpha
Review this target as Amiloride-sensitive sodium channel subunit alpha, mapped to UniProt P37088. ChEMBL maps the protein component as Epithelial sodium channel subunit alpha. Sequence length is 669 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Amiloride-sensitive sodium channel subunit alpha as ChEMBL target CHEMBL1791, mapped to UniProt P37088. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Amiloride-sensitive sodium channel subunit alpha |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P37088 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Epithelial sodium channel subunit alpha |
| UniProt Accession | P37088 |
| Component Type | Protein |
| Sequence Length | 669 aa |
Epithelial sodium channel subunit alpha
Review this target as Amiloride-sensitive sodium channel subunit alpha, mapped to UniProt P37088. ChEMBL maps the protein component as Epithelial sodium channel subunit alpha. Sequence length is 669 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL212431 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL212531 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL212432 | 8.1 | IC50 | 8.0 | Clinical |
| CHEMBL211161 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL209303 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL214239 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL377986 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL210876 | 7.77 | IC50 | 17.0 | Preclinical |
| CHEMBL211600 | 7.77 | IC50 | 17.0 | Preclinical |
| CHEMBL380011 | 7.7 | IC50 | 20.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 42 | 7.4 |