Apoptotic protease-activating factor 1 · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt O14727. Use UniProt O14727 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O14727 as the stable identity anchor, then attach disease evidence before program review.
Apoptotic protease-activating factor 1
Review this target as Apoptotic protease-activating factor 1, mapped to UniProt O14727. Sequence length is 1248 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Apoptotic protease-activating factor 1 as ChEMBL target CHEMBL1795093, mapped to UniProt O14727. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Apoptotic protease-activating factor 1 is the right protein anchor across sources, using UniProt O14727 as the stable mapping.
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| Preferred Name | Apoptotic protease-activating factor 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O14727 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Apoptotic protease-activating factor 1 |
| UniProt Accession | O14727 |
| Component Type | Protein |
| Sequence Length | 1248 aa |
Apoptotic protease-activating factor 1
Review this target as Apoptotic protease-activating factor 1, mapped to UniProt O14727. Sequence length is 1248 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL601757 | 7.43 | IC50 | 37.5 | Preclinical |
| CHEMBL599924 | 7.24 | IC50 | 57.2 | Preclinical |
| CHEMBL1463659 | 7.1 | IC50 | 79.0 | Preclinical |
| CHEMBL1583199 | 6.74 | IC50 | 181.0 | Preclinical |
| CHEMBL1498509 | 6.5 | IC50 | 316.0 | Preclinical |
| CHEMBL3189714 | 6.47 | IC50 | 335.0 | Preclinical |
| CHEMBL3192555 | 6.39 | IC50 | 411.0 | Preclinical |
| CHEMBL3191855 | 6.36 | IC50 | 441.0 | Preclinical |
| CHEMBL3196451 | 6.34 | IC50 | 453.0 | Preclinical |
| CHEMBL51931 | 6.26 | IC50 | 549.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 8 | 493 | 4.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 0 | — |