Protein arginine N-methyltransferase 5 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein arginine N-methyltransferase 5 shows clinical signal disease relevance led by breast cancer. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt O14744. Start with breast cancer, then reuse UniProt O14744 as the stable protein anchor across project notes and exports.
Start with breast cancer, then reuse UniProt O14744 as the stable protein anchor across project notes and exports.
Protein arginine N-methyltransferase 5 shows clinical signal disease relevance led by breast cancer. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with breast cancer because it currently carries clinical signal support. Linked drugs include PEMRAMETOSTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyProtein arginine N-methyltransferase 5
Review this target as Protein arginine N-methyltransferase 5, mapped to UniProt O14744. Sequence length is 637 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Protein arginine N-methyltransferase 5 as ChEMBL target CHEMBL1795116, mapped to UniProt O14744. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Protein arginine N-methyltransferase 5 is the right protein anchor across sources, using UniProt O14744 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why breast cancer is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | Protein arginine N-methyltransferase 5 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O14744 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein arginine N-methyltransferase 5 |
| UniProt Accession | O14744 |
| Component Type | Protein |
| Sequence Length | 637 aa |
Protein arginine N-methyltransferase 5
Review this target as Protein arginine N-methyltransferase 5, mapped to UniProt O14744. Sequence length is 637 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Protein arginine N-methyltransferase 5 shows clinical signal disease relevance led by breast cancer. 1 more disease program remain visible in the same review block.
Start review with breast cancer because it currently carries clinical signal support. Linked drugs include PEMRAMETOSTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4441584 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL5180177 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL5203719 | 9.89 | IC50 | 0.13 | Preclinical |
| CHEMBL4249337 | 9.85 | IC50 | 0.14 | Preclinical |
| CHEMBL4541714 | 9.8 | IC50 | 0.16 | Preclinical |
| CHEMBL4543007 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL5187591 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL5283866 | 9.38 | IC50 | 0.42 | Preclinical |
| CHEMBL5559161 | 9.38 | IC50 | 0.42 | Preclinical |
| CHEMBL5560909 | 9.38 | IC50 | 0.42 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 213 | 553 | 6.7 |
| single protein format | 152 | 505 | 6.7 |
| assay format | 7 | 244 | 6.4 |
| tissue-based format | 2 | 4 | 8.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 6 | 4 | 7.0 |
| cell-based format | 2 | 2 | 7.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |