Histone-lysine N-methyltransferase, H3 lysine-79 specific · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q8TEK3. Use UniProt Q8TEK3 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8TEK3 as the stable identity anchor, then attach disease evidence before program review.
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Review this target as Histone-lysine N-methyltransferase, H3 lysine-79 specific, mapped to UniProt Q8TEK3. Sequence length is 1537 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histone-lysine N-methyltransferase, H3 lysine-79 specific as ChEMBL target CHEMBL1795117, mapped to UniProt Q8TEK3. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Histone-lysine N-methyltransferase, H3 lysine-79 specific |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8TEK3 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histone-lysine N-methyltransferase, H3 lysine-79 specific |
| UniProt Accession | Q8TEK3 |
| Component Type | Protein |
| Sequence Length | 1537 aa |
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Review this target as Histone-lysine N-methyltransferase, H3 lysine-79 specific, mapped to UniProt Q8TEK3. Sequence length is 1537 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5764114 | 11.0 | Kd | 0.01 | Preclinical |
| CHEMBL3414626 | 10.92 | Ki | 0.012 | Clinical |
| CHEMBL3087498 | 10.25 | Kd | 0.0561 | Preclinical |
| CHEMBL4590355 | 10.1 | Ki | 0.08 | Preclinical |
| CHEMBL4446126 | 9.96 | IC50 | 0.11 | Preclinical |
| CHEMBL4081752 | 9.82 | IC50 | 0.15 | Preclinical |
| CHEMBL4435508 | 9.77 | IC50 | 0.17 | Preclinical |
| CHEMBL4567485 | 9.72 | IC50 | 0.19 | Preclinical |
| CHEMBL2169919 | 9.6 | Kd | 0.25 | Preclinical |
| CHEMBL5176983 | 9.52 | IC50 | 0.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 126 | 152 | 6.8 |
| cell-based format | 39 | 20 | 6.7 |
| assay format | 33 | 54 | 6.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |