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Target Snapshot

CHEMBL1795127 Target Snapshot

Thymidine kinase · SINGLE PROTEIN · Human herpesvirus 1

130Compounds
18Assays
2Approved Drugs
118.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9QNF7. Use UniProt Q9QNF7 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9QNF7 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Thymidine kinase as ChEMBL target CHEMBL1795127, mapped to UniProt Q9QNF7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Thymidine kinase
SINGLE PROTEIN · Human herpesvirus 1
As of 2026-09-14
ChEMBL target ID
CHEMBL1795127
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9QNF7
Thymidine kinase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Thymidine kinase is the right protein anchor across sources, using UniProt Q9QNF7 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelThymidine kinase
UniProt AccessionQ9QNF7
Component TypeProtein
Sequence Length376 aa

Thymidine kinase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Thymidine kinase, mapped to UniProt Q9QNF7. Sequence length is 376 aa.

Mapped IDQ9QNF7
Review nameThymidine kinase
OrganismHuman herpesvirus 1
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC50115.0
KI3.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL405761 6.82 IC50 150.0 Preclinical
CHEMBL406254 6.8 IC50 160.0 Preclinical
CHEMBL31634 6.62 Ki 240.0 Clinical
CHEMBL3143935 6.52 IC50 300.0 Preclinical
CHEMBL3143935 6.52 Ki 300.0 Preclinical
CHEMBL152256 6.35 IC50 450.0 Preclinical
CHEMBL152338 6.35 IC50 450.0 Preclinical
CHEMBL154209 6.21 IC50 610.0 Preclinical
CHEMBL153866 6.19 IC50 650.0 Preclinical
CHEMBL219299 6.16 IC50 700.0 Preclinical
Distribution

pChEMBL Value Distribution

15
5.0
12
5.5
7
6.0
6
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

18
Total Assays
60
Tested Compounds
2
Assay Types
Binding — 15 assays, 60 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 15 60 5.2
Functional — 3 assays, 29 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 3 29 5.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine