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Target Snapshot

CHEMBL1795135 Target Snapshot

3-oxoacyl-[acyl-carrier-protein] synthase 3 · SINGLE PROTEIN · Escherichia coli

261Compounds
15Assays
1Approved Drugs
256.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt C3TDZ2. Use UniProt C3TDZ2 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt C3TDZ2 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Protein anchor
Beta-ketoacyl-[acyl-carrier-protein] synthase III

Beta-ketoacyl-[acyl-carrier-protein] synthase III

Review this target as 3-oxoacyl-[acyl-carrier-protein] synthase 3, mapped to UniProt C3TDZ2. ChEMBL maps the protein component as Beta-ketoacyl-[acyl-carrier-protein] synthase III. Sequence length is 317 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt C3TDZ2 Protein 317 aa
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Identity Layer

Cross-source identity

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This review treats 3-oxoacyl-[acyl-carrier-protein] synthase 3 as ChEMBL target CHEMBL1795135, mapped to UniProt C3TDZ2. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
3-oxoacyl-[acyl-carrier-protein] synthase 3
SINGLE PROTEIN · Escherichia coli
As of 2026-09-14
ChEMBL target ID
CHEMBL1795135
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
C3TDZ2
Beta-ketoacyl-[acyl-carrier-protein] synthase III
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

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UniProt Target Context
UniProt accession via ChEMBL component mapping

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBeta-ketoacyl-[acyl-carrier-protein] synthase III
UniProt AccessionC3TDZ2
Component TypeProtein
Sequence Length317 aa

Beta-ketoacyl-[acyl-carrier-protein] synthase III

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as 3-oxoacyl-[acyl-carrier-protein] synthase 3, mapped to UniProt C3TDZ2. ChEMBL maps the protein component as Beta-ketoacyl-[acyl-carrier-protein] synthase III. Sequence length is 317 aa.

Mapped IDC3TDZ2
Review name3-oxoacyl-[acyl-carrier-protein] synthase 3
OrganismEscherichia coli
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC50220.0
KI36.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL391599 6.05 IC50 900.0 Preclinical
CHEMBL233867 5.96 IC50 1100.0 Preclinical
CHEMBL4446312 5.91 IC50 1220.0 Preclinical
CHEMBL397859 5.72 IC50 1900.0 Preclinical
CHEMBL4514635 5.69 IC50 2050.0 Preclinical
CHEMBL1232305 5.68 IC50 2100.0 Preclinical
CHEMBL234754 5.62 IC50 2400.0 Preclinical
CHEMBL1807657 5.6 IC50 2500.0 Preclinical
CHEMBL1808653 5.58 IC50 2600.0 Preclinical
CHEMBL4476826 5.51 IC50 3060.0 Preclinical
Distribution

pChEMBL Value Distribution

17
5.0
9
5.5
1
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

15
Total Assays
116
Tested Compounds
1
Assay Types
Binding — 15 assays, 116 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 8 57 4.7
assay format 4 25 4.8
cell-based format 3 34 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine