Transmembrane protease serine 6 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q8IU80. Use UniProt Q8IU80 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8IU80 as the stable identity anchor, then attach disease evidence before program review.
Transmembrane protease serine 6
Review this target as Transmembrane protease serine 6, mapped to UniProt Q8IU80. Sequence length is 811 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Transmembrane protease serine 6 as ChEMBL target CHEMBL1795139, mapped to UniProt Q8IU80. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Transmembrane protease serine 6 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8IU80 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Transmembrane protease serine 6 |
| UniProt Accession | Q8IU80 |
| Component Type | Protein |
| Sequence Length | 811 aa |
Transmembrane protease serine 6
Review this target as Transmembrane protease serine 6, mapped to UniProt Q8IU80. Sequence length is 811 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2086421 | 10.96 | Ki | 0.011 | Preclinical |
| CHEMBL2089123 | 10.06 | Ki | 0.088 | Preclinical |
| CHEMBL5982921 | 9.87 | Ki | 0.134 | Preclinical |
| CHEMBL4081543 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL5557224 | 9.3 | Ki | 0.506 | Preclinical |
| CHEMBL3354675 | 9.13 | Ki | 0.74 | Preclinical |
| CHEMBL3354683 | 8.99 | Ki | 1.03 | Preclinical |
| CHEMBL4093487 | 8.96 | Ki | 1.1 | Preclinical |
| CHEMBL4103740 | 8.92 | Ki | 1.2 | Preclinical |
| CHEMBL5562941 | 8.92 | Ki | 1.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 11 | 113 | 6.3 |
| single protein format | 9 | 41 | 8.2 |