Transmembrane protease serine 2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt O15393. Use UniProt O15393 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O15393 as the stable identity anchor, then attach disease evidence before program review.
Transmembrane protease serine 2
Review this target as Transmembrane protease serine 2, mapped to UniProt O15393. Sequence length is 492 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Transmembrane protease serine 2 as ChEMBL target CHEMBL1795140, mapped to UniProt O15393. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Transmembrane protease serine 2 is the right protein anchor across sources, using UniProt O15393 as the stable mapping.
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| Preferred Name | Transmembrane protease serine 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O15393 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Transmembrane protease serine 2 |
| UniProt Accession | O15393 |
| Component Type | Protein |
| Sequence Length | 492 aa |
Transmembrane protease serine 2
Review this target as Transmembrane protease serine 2, mapped to UniProt O15393. Sequence length is 492 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL273264 | 9.3 | IC50 | 0.5 | Clinical |
| CHEMBL3219079 | 9.05 | Ki | 0.9 | Preclinical |
| CHEMBL5560415 | 9.01 | IC50 | 0.98 | Preclinical |
| CHEMBL3219087 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL5557551 | 8.92 | IC50 | 1.2 | Preclinical |
| CHEMBL5558547 | 8.92 | IC50 | 1.2 | Preclinical |
| CHEMBL5620212 | 8.77 | IC50 | 1.7 | Preclinical |
| CHEMBL5555448 | 8.6 | IC50 | 2.5 | Preclinical |
| CHEMBL3219101 | 8.52 | Ki | 3.0 | Preclinical |
| CHEMBL3219100 | 8.52 | Ki | 3.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 12 | 34 | 7.0 |
| assay format | 3 | 12 | 7.5 |
| tissue-based format | 3 | 0 | — |
| cell-based format | 1 | 1 | 6.0 |