Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) · SINGLE PROTEIN · Escherichia coli
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As of 2026-09-13Protein identity stays anchored to UniProt E2QDN0. Use UniProt E2QDN0 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt E2QDN0 as the stable identity anchor, then attach disease evidence before program review.
Thymidylate synthase
Review this target as Thymidylate synthase (EC 2.1.1.45) (TS) (TSase), mapped to UniProt E2QDN0. ChEMBL maps the protein component as Thymidylate synthase. Sequence length is 367 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) as ChEMBL target CHEMBL1795153, mapped to UniProt E2QDN0. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) |
| Target Type | SINGLE PROTEIN |
| Organism | Escherichia coli |
| UniProt | E2QDN0 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Thymidylate synthase |
| UniProt Accession | E2QDN0 |
| Component Type | Protein |
| Sequence Length | 367 aa |
Thymidylate synthase
Review this target as Thymidylate synthase (EC 2.1.1.45) (TS) (TSase), mapped to UniProt E2QDN0. ChEMBL maps the protein component as Thymidylate synthase. Sequence length is 367 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1738741 | 7.77 | IC50 | 17.0 | Preclinical |
| CHEMBL169896 | 7.64 | IC50 | 23.0 | Clinical |
| CHEMBL389051 | 7.32 | IC50 | 48.0 | Preclinical |
| CHEMBL1738740 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL225180 | 6.68 | IC50 | 210.0 | Preclinical |
| CHEMBL1818548 | 6.09 | IC50 | 820.0 | Preclinical |
| CHEMBL1818549 | 6.07 | IC50 | 850.0 | Preclinical |
| CHEMBL225072 | 4.12 | IC50 | 76000.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 8 | 6.6 |