Toll-like receptor 4 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt Q9QUK6. Use UniProt Q9QUK6 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9QUK6 as the stable identity anchor, then attach disease evidence before program review.
Toll-like receptor 4
Review this target as Toll-like receptor 4, mapped to UniProt Q9QUK6. Sequence length is 835 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Toll-like receptor 4 as ChEMBL target CHEMBL1795167, mapped to UniProt Q9QUK6. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Toll-like receptor 4 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | Q9QUK6 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Toll-like receptor 4 |
| UniProt Accession | Q9QUK6 |
| Component Type | Protein |
| Sequence Length | 835 aa |
Toll-like receptor 4
Review this target as Toll-like receptor 4, mapped to UniProt Q9QUK6. Sequence length is 835 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL507938 | 10.82 | EC50 | 0.015 | Preclinical |
| CHEMBL5407900 | 10.7 | EC50 | 0.02 | Preclinical |
| CHEMBL5423611 | 10.52 | EC50 | 0.03 | Preclinical |
| CHEMBL5407887 | 10.4 | EC50 | 0.04 | Preclinical |
| CHEMBL5433813 | 10.05 | EC50 | 0.09 | Preclinical |
| CHEMBL5432710 | 9.59 | EC50 | 0.26 | Preclinical |
| CHEMBL5422378 | 9.51 | EC50 | 0.31 | Preclinical |
| CHEMBL5428754 | 9.37 | EC50 | 0.43 | Preclinical |
| CHEMBL5417929 | 9.31 | EC50 | 0.49 | Preclinical |
| CHEMBL225157 | 8.89 | IC50 | 1.3 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 141 | 100 | 6.1 |
| single protein format | 27 | 13 | 4.9 |
| assay format | 4 | 0 | — |
| tissue-based format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |