Mitogen-activated protein kinase 8 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt Q91Y86. Use UniProt Q91Y86 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q91Y86 as the stable identity anchor, then attach disease evidence before program review.
Mitogen-activated protein kinase 8
Review this target as Mitogen-activated protein kinase 8, mapped to UniProt Q91Y86. Sequence length is 384 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase 8 as ChEMBL target CHEMBL1795174, mapped to UniProt Q91Y86. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Mitogen-activated protein kinase 8 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | Q91Y86 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase 8 |
| UniProt Accession | Q91Y86 |
| Component Type | Protein |
| Sequence Length | 384 aa |
Mitogen-activated protein kinase 8
Review this target as Mitogen-activated protein kinase 8, mapped to UniProt Q91Y86. Sequence length is 384 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4862452 | 6.77 | IC50 | 170.0 | Preclinical |
| CHEMBL4877655 | 6.68 | IC50 | 210.0 | Preclinical |
| CHEMBL4878046 | 6.67 | IC50 | 212.0 | Preclinical |
| CHEMBL4874549 | 6.46 | IC50 | 350.0 | Preclinical |
| CHEMBL4847078 | 6.4 | IC50 | 400.0 | Preclinical |
| CHEMBL4872066 | 6.26 | IC50 | 550.0 | Preclinical |
| CHEMBL4853125 | 6.24 | IC50 | 580.0 | Preclinical |
| CHEMBL1950289 | 5.95 | IC50 | 1120.0 | Clinical |
| CHEMBL4861369 | 5.84 | IC50 | 1450.0 | Preclinical |
| CHEMBL4874419 | 5.75 | IC50 | 1770.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 9 | 14 | 6.0 |
| subcellular format | 2 | 1 | 5.3 |