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Target Snapshot

CHEMBL1795180 Target Snapshot

Free fatty acid receptor 1 · SINGLE PROTEIN · Rattus norvegicus

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252Compounds
54Assays
0Approved Drugs
272.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q8K3T4. Use UniProt Q8K3T4 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q8K3T4 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Free fatty acid receptor 1 as ChEMBL target CHEMBL1795180, mapped to UniProt Q8K3T4. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Free fatty acid receptor 1
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL1795180
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q8K3T4
Free fatty acid receptor 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Free fatty acid receptor 1 is the right protein anchor across sources, using UniProt Q8K3T4 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameFree fatty acid receptor 1
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtQ8K3T4
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelFree fatty acid receptor 1
UniProt AccessionQ8K3T4
Component TypeProtein
Sequence Length300 aa

Free fatty acid receptor 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Free fatty acid receptor 1, mapped to UniProt Q8K3T4. Sequence length is 300 aa.

Mapped IDQ8K3T4
Review nameFree fatty acid receptor 1
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

1
Phase III
1
Phase I
Assay Mix

Activity Type Distribution

IC503.0
KI79.0
EC50190.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4541658 9.51 EC50 0.31 Preclinical
CHEMBL4457303 9.47 EC50 0.34 Preclinical
CHEMBL3923877 9.4 EC50 0.4 Preclinical
CHEMBL4463571 9.4 EC50 0.4 Preclinical
CHEMBL4165147 9.31 EC50 0.49 Preclinical
CHEMBL4793371 9.27 EC50 0.54 Preclinical
CHEMBL4788206 9.23 EC50 0.59 Preclinical
CHEMBL4797858 9.08 EC50 0.83 Preclinical
CHEMBL4785057 9.05 EC50 0.89 Preclinical
CHEMBL4782004 9.03 EC50 0.93 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
9
5.5
19
6.0
52
6.5
50
7.0
59
7.5
32
8.0
12
8.5
10
9.0
1
9.5
pChEMBL
Assay Landscape

Assay Landscape

54
Total Assays
154
Tested Compounds
2
Assay Types
Binding — 28 assays, 154 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 13 97 7.3
single protein format 8 4 6.9
assay format 5 47 7.2
cell membrane format 1 6 6.3
tissue-based format 1 0 —
Functional — 26 assays, 92 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 22 88 7.5
assay format 2 4 7.7
organism-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine