Receptor-interacting serine/threonine-protein kinase 3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9Y572. Use UniProt Q9Y572 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9Y572 as the stable identity anchor, then attach disease evidence before program review.
Receptor-interacting serine/threonine-protein kinase 3
Review this target as Receptor-interacting serine/threonine-protein kinase 3, mapped to UniProt Q9Y572. Sequence length is 518 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Receptor-interacting serine/threonine-protein kinase 3 as ChEMBL target CHEMBL1795199, mapped to UniProt Q9Y572. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Receptor-interacting serine/threonine-protein kinase 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y572 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Receptor-interacting serine/threonine-protein kinase 3 |
| UniProt Accession | Q9Y572 |
| Component Type | Protein |
| Sequence Length | 518 aa |
Receptor-interacting serine/threonine-protein kinase 3
Review this target as Receptor-interacting serine/threonine-protein kinase 3, mapped to UniProt Q9Y572. Sequence length is 518 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4439913 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL4470115 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL4779280 | 8.89 | IC50 | 1.3 | Preclinical |
| CHEMBL5407694 | 8.87 | Kd | 1.35 | Preclinical |
| CHEMBL1171837 | 8.8 | IC50 | 1.6 | Approved |
| CHEMBL2028663 | 8.7 | IC50 | 2.0 | Approved |
| CHEMBL4455682 | 8.54 | IC50 | 2.9 | Preclinical |
| CHEMBL400402 | 8.52 | Kd | 3.0 | Preclinical |
| CHEMBL4441118 | 8.19 | IC50 | 6.5 | Preclinical |
| CHEMBL4861646 | 8.14 | Kd | 7.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 59 | 173 | 6.0 |
| cell-based format | 47 | 35 | 6.3 |
| assay format | 15 | 29 | 7.4 |
| subcellular format | 7 | 40 | 6.2 |
| tissue-based format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |