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Target Snapshot

CHEMBL1795200 Target Snapshot

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase · SINGLE PROTEIN · Yersinia pestis

6Compounds
1Assays
0Approved Drugs
6.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q8ZEY1. Use UniProt Q8ZEY1 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q8ZEY1 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase as ChEMBL target CHEMBL1795200, mapped to UniProt Q8ZEY1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
SINGLE PROTEIN · Yersinia pestis
As of 2026-09-14
ChEMBL target ID
CHEMBL1795200
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q8ZEY1
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase is the right protein anchor across sources, using UniProt Q8ZEY1 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
UniProt AccessionQ8ZEY1
Component TypeProtein
Sequence Length299 aa

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, mapped to UniProt Q8ZEY1. Sequence length is 299 aa.

Mapped IDQ8ZEY1
Review name4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
OrganismYersinia pestis
Assay Mix

Activity Type Distribution

IC506.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1835608 5.22 IC50 6000.0 Preclinical
CHEMBL493923 5.05 IC50 9000.0 Preclinical
CHEMBL80658 4.92 IC50 12000.0 Preclinical
CHEMBL1342017 4.89 IC50 13000.0 Preclinical
CHEMBL1835595 4.89 IC50 13000.0 Preclinical
CHEMBL1835581 4.82 IC50 15000.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
6
Tested Compounds
1
Assay Types
Binding — 1 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 6 5.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine