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Target Snapshot

CHEMBL1798 Target Snapshot

Cysteinyl leukotriene receptor 1 · SINGLE PROTEIN · Homo sapiens

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1,164Compounds
84Assays
11Approved Drugs
1,962.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Cysteinyl leukotriene receptor 1 shows approved-linked disease relevance led by Airway obstruction. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q9Y271. Start with Airway obstruction, then reuse UniProt Q9Y271 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with Airway obstruction, then reuse UniProt Q9Y271 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 2 linked drugs
Open source guide
Disease program
Airway obstruction

Cysteinyl leukotriene receptor 1 shows approved-linked disease relevance led by Airway obstruction. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.

Start review with Airway obstruction because it currently carries approved-linked support. Linked drugs include PRANLUKAST, ZAFIRLUKAST. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 2 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cysteinyl leukotriene receptor 1 as ChEMBL target CHEMBL1798, mapped to UniProt Q9Y271. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cysteinyl leukotriene receptor 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1798
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9Y271
Cysteinyl leukotriene receptor 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cysteinyl leukotriene receptor 1 is the right protein anchor across sources, using UniProt Q9Y271 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why Airway obstruction is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameCysteinyl leukotriene receptor 1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9Y271
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCysteinyl leukotriene receptor 1
UniProt AccessionQ9Y271
Component TypeProtein
Sequence Length337 aa

Cysteinyl leukotriene receptor 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Cysteinyl leukotriene receptor 1, mapped to UniProt Q9Y271. Sequence length is 337 aa.

Mapped IDQ9Y271
Review nameCysteinyl leukotriene receptor 1
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Cysteinyl leukotriene receptor 1 shows approved-linked disease relevance led by Airway obstruction. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
Airway obstruction
2 linked drugs · 2 direct · 2 efficacy
Linked drugPRANLUKAST
Linked drugZAFIRLUKAST
Approved-linked Approved
asthma
2 linked drugs · 2 direct · 2 efficacy
Linked drugMONTELUKAST SODIUM
Linked drugZAFIRLUKAST
Approved-linked Approved
seasonal allergic rhinitis
2 linked drugs · 2 direct · 2 efficacy
Linked drugMONTELUKAST SODIUM
Linked drugPRANLUKAST
Approved-linked Approved
allergic rhinitis
1 linked drug · 1 direct · 1 efficacy
Linked drugMONTELUKAST SODIUM
Approved-linked Approved
allergic rhinitis
1 linked drug · 1 direct · 1 efficacy
Linked drugMONTELUKAST SODIUM
Approved-linked Approved
asthma
1 linked drug · 1 direct · 1 efficacy
Linked drugMONTELUKAST SODIUM
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with Airway obstruction because it currently carries approved-linked support. Linked drugs include PRANLUKAST, ZAFIRLUKAST. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseAirway obstruction
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

11
Approved
4
Phase II
Assay Mix

Activity Type Distribution

IC501,104.0
KI840.0
EC508.0
KD10.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL48435 10.1 Kd 0.07943 Preclinical
CHEMBL4280282 10.0 Kd 0.1 Preclinical
CHEMBL344180 9.72 IC50 0.19 Preclinical
CHEMBL139757 9.68 IC50 0.21 Preclinical
CHEMBL3597618 9.66 IC50 0.22 Preclinical
CHEMBL603 9.59 IC50 0.26 Approved
CHEMBL288943 9.54 Ki 0.29 Preclinical
CHEMBL3597617 9.49 IC50 0.32 Preclinical
CHEMBL341603 9.47 IC50 0.34 Preclinical
CHEMBL313187 9.42 IC50 0.38 Preclinical
Distribution

pChEMBL Value Distribution

11
5.0
17
5.5
24
6.0
26
6.5
28
7.0
42
7.5
37
8.0
41
8.5
32
9.0
6
9.5
pChEMBL
Approved Drugs

Approved Drugs

MONTELUKAST
CHEMBL787
Approved 1998
Properties Compare Identifier
MONTELUKAST SODIUM
CHEMBL1200681
Approved 1998
Properties Compare Identifier
ZAFIRLUKAST
CHEMBL603
Approved 1996
Properties Compare Identifier
PRANLUKAST
CHEMBL21333
Approved 1995
Properties Compare Identifier
Assay Landscape

Assay Landscape

84
Total Assays
209
Tested Compounds
3
Assay Types
Binding — 61 assays, 53 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 46 7 7.9
cell-based format 11 36 8.9
cell membrane format 2 7 6.3
tissue-based format 2 3 8.2
Functional — 22 assays, 209 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 14 199 7.4
assay format 6 10 7.4
organism-based format 1 0 —
tissue-based format 1 0 —
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine