DNA topoisomerase 2-alpha · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14DNA topoisomerase 2-alpha shows approved-linked disease relevance led by acute myeloid leukemia. 5 more disease programs remain visible in the same review block. 6 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P11388. Start with acute myeloid leukemia, then reuse UniProt P11388 as the stable protein anchor across project notes and exports.
Start with acute myeloid leukemia, then reuse UniProt P11388 as the stable protein anchor across project notes and exports.
DNA topoisomerase 2-alpha shows approved-linked disease relevance led by acute myeloid leukemia. 5 more disease programs remain visible in the same review block. 6 linked drugs remain visible in the same block.
Start review with acute myeloid leukemia because it currently carries approved-linked support. Linked drugs include DAUNORUBICIN, DAUNORUBICIN HYDROCHLORIDE, DOXORUBICIN HYDROCHLORIDE, ETOPOSIDE PHOSPHATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyDNA topoisomerase 2-alpha
Review this target as DNA topoisomerase 2-alpha, mapped to UniProt P11388. Sequence length is 1531 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats DNA topoisomerase 2-alpha as ChEMBL target CHEMBL1806, mapped to UniProt P11388. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether DNA topoisomerase 2-alpha is the right protein anchor across sources, using UniProt P11388 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why acute myeloid leukemia is currently framed as approved-linked support. It currently carries 6 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | DNA topoisomerase 2-alpha |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P11388 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA topoisomerase 2-alpha |
| UniProt Accession | P11388 |
| Component Type | Protein |
| Sequence Length | 1531 aa |
DNA topoisomerase 2-alpha
Review this target as DNA topoisomerase 2-alpha, mapped to UniProt P11388. Sequence length is 1531 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
DNA topoisomerase 2-alpha shows approved-linked disease relevance led by acute myeloid leukemia. 5 more disease programs remain visible in the same review block.
Start review with acute myeloid leukemia because it currently carries approved-linked support. Linked drugs include DAUNORUBICIN, DAUNORUBICIN HYDROCHLORIDE, DOXORUBICIN HYDROCHLORIDE, ETOPOSIDE PHOSPHATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL440125 | 9.68 | IC50 | 0.21 | Preclinical |
| CHEMBL1232279 | 8.82 | IC50 | 1.5 | Clinical |
| CHEMBL1117 | 8.59 | IC50 | 2.6 | Approved |
| CHEMBL417 | 8.52 | IC50 | 3.0 | Approved |
| CHEMBL53463 | 8.31 | IC50 | 4.9 | Approved |
| CHEMBL178 | 8.0 | IC50 | 10.0 | Approved |
| CHEMBL3752910 | 7.27 | Kd | 54.1 | Preclinical |
| CHEMBL5653589 | 7.25 | Kd | 56.27 | Preclinical |
| CHEMBL346068 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL3039513 | 7.19 | Kd | 64.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 888 | 402 | 5.0 |
| cell-based format | 124 | 24 | 4.9 |
| assay format | 76 | 25 | 5.4 |
| subcellular format | 2 | 2 | 6.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 16 | 4 | 5.5 |
| cell-based format | 5 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 0 | — |
| assay format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |