Dihydrofolate reductase · SINGLE PROTEIN · Escherichia coli
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As of 2026-09-13Protein identity stays anchored to UniProt P0ABQ4. Use UniProt P0ABQ4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P0ABQ4 as the stable identity anchor, then attach disease evidence before program review.
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt P0ABQ4. Sequence length is 159 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydrofolate reductase as ChEMBL target CHEMBL1809, mapped to UniProt P0ABQ4. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dihydrofolate reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Escherichia coli |
| UniProt | P0ABQ4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydrofolate reductase |
| UniProt Accession | P0ABQ4 |
| Component Type | Protein |
| Sequence Length | 159 aa |
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt P0ABQ4. Sequence length is 159 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL286400 | 10.92 | Ki | 0.01202 | Preclinical |
| CHEMBL34259 | 10.68 | Ki | 0.021 | Approved |
| CHEMBL34259 | 10.64 | Kd | 0.023 | Approved |
| CHEMBL14001 | 10.62 | Ki | 0.02399 | Preclinical |
| CHEMBL31713 | 10.54 | Ki | 0.02884 | Preclinical |
| CHEMBL31887 | 10.49 | Ki | 0.03236 | Preclinical |
| CHEMBL418347 | 10.46 | Ki | 0.03467 | Preclinical |
| CHEMBL31924 | 10.4 | Ki | 0.03981 | Preclinical |
| CHEMBL274430 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL13673 | 10.18 | Ki | 0.066 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 189 | 521 | 6.9 |
| cell-based format | 5 | 11 | 7.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |