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Target Snapshot

CHEMBL1811 Target Snapshot

Prostaglandin E2 receptor EP1 subtype · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
1,325Compounds
167Assays
8Approved Drugs
1,436.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Prostaglandin E2 receptor EP1 subtype shows approved-linked disease relevance led by cardiovascular disease. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P34995. Start with cardiovascular disease, then reuse UniProt P34995 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with cardiovascular disease, then reuse UniProt P34995 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
cardiovascular disease

Prostaglandin E2 receptor EP1 subtype shows approved-linked disease relevance led by cardiovascular disease. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with cardiovascular disease because it currently carries approved-linked support. Linked drugs include ALPROSTADIL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Prostaglandin E2 receptor EP1 subtype as ChEMBL target CHEMBL1811, mapped to UniProt P34995. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Prostaglandin E2 receptor EP1 subtype
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1811
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P34995
Prostaglandin E2 receptor EP1 subtype
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Prostaglandin E2 receptor EP1 subtype is the right protein anchor across sources, using UniProt P34995 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why cardiovascular disease is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameProstaglandin E2 receptor EP1 subtype
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP34995
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProstaglandin E2 receptor EP1 subtype
UniProt AccessionP34995
Component TypeProtein
Sequence Length402 aa

Prostaglandin E2 receptor EP1 subtype

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Prostaglandin E2 receptor EP1 subtype, mapped to UniProt P34995. Sequence length is 402 aa.

Mapped IDP34995
Review nameProstaglandin E2 receptor EP1 subtype
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Prostaglandin E2 receptor EP1 subtype shows approved-linked disease relevance led by cardiovascular disease. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
cardiovascular disease
1 linked drug · 1 direct · 1 efficacy
Linked drugALPROSTADIL
Approved-linked Approved
erectile dysfunction
1 linked drug · 1 direct · 1 efficacy
Linked drugALPROSTADIL
Approved-linked Approved
Patent ductus arteriosus
1 linked drug · 1 direct · 1 efficacy
Linked drugALPROSTADIL
Late clinical Phase III
heart failure
1 linked drug · 1 direct · 1 efficacy
Linked drugALPROSTADIL
Late clinical Phase III
macular degeneration
1 linked drug · 1 direct · 1 efficacy
Linked drugALPROSTADIL
Late clinical Phase III
prostate cancer
1 linked drug · 1 direct · 1 efficacy
Linked drugALPROSTADIL
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with cardiovascular disease because it currently carries approved-linked support. Linked drugs include ALPROSTADIL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasecardiovascular disease
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

8
Approved
1
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC50764.0
KI515.0
EC50143.0
KD14.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL402392 10.2 Ki 0.0631 Preclinical
CHEMBL427844 10.0 Ki 0.1 Preclinical
CHEMBL2110364 9.89 IC50 0.1288 Preclinical
CHEMBL214971 9.88 IC50 0.1318 Preclinical
CHEMBL257134 9.7 Ki 0.1995 Preclinical
CHEMBL494 9.52 EC50 0.3 Approved
CHEMBL362543 9.52 Ki 0.3 Preclinical
CHEMBL4129609 9.52 IC50 0.3 Preclinical
CHEMBL403330 9.5 Ki 0.3162 Preclinical
CHEMBL387969 9.4 IC50 0.3981 Preclinical
Distribution

pChEMBL Value Distribution

48
5.0
57
5.5
92
6.0
125
6.5
195
7.0
152
7.5
154
8.0
57
8.5
27
9.0
8
9.5
pChEMBL
Approved Drugs

Approved Drugs

ILOPROST
CHEMBL494
Approved 2003
Properties Compare Identifier
TREPROSTINIL
CHEMBL1237119
Approved 2002
Properties Compare Identifier
DINOPROST
CHEMBL815
Approved 1982
Properties Compare Identifier
DINOPROSTONE
CHEMBL548
Approved 1977
Properties Compare Identifier
Assay Landscape

Assay Landscape

167
Total Assays
711
Tested Compounds
3
Assay Types
Binding — 112 assays, 711 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 71 261 6.8
cell-based format 38 444 7.3
cell membrane format 1 0 —
cell-free format 1 6 6.2
tissue-based format 1 0 —
Functional — 54 assays, 196 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 37 159 7.2
assay format 13 27 7.5
single protein format 2 1 5.9
tissue-based format 2 9 6.6
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine