Pancreatic triacylglycerol lipase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Pancreatic triacylglycerol lipase shows approved-linked disease relevance led by obesity. 4 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P16233. Start with obesity, then reuse UniProt P16233 as the stable protein anchor across project notes and exports.
Start with obesity, then reuse UniProt P16233 as the stable protein anchor across project notes and exports.
Pancreatic triacylglycerol lipase shows approved-linked disease relevance led by obesity. 4 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with obesity because it currently carries approved-linked support. Linked drugs include CETILISTAT, ORLISTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyPancreatic triacylglycerol lipase
Review this target as Pancreatic triacylglycerol lipase, mapped to UniProt P16233. Sequence length is 465 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Pancreatic triacylglycerol lipase as ChEMBL target CHEMBL1812, mapped to UniProt P16233. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Pancreatic triacylglycerol lipase is the right protein anchor across sources, using UniProt P16233 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why obesity is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | Pancreatic triacylglycerol lipase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P16233 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Pancreatic triacylglycerol lipase |
| UniProt Accession | P16233 |
| Component Type | Protein |
| Sequence Length | 465 aa |
Pancreatic triacylglycerol lipase
Review this target as Pancreatic triacylglycerol lipase, mapped to UniProt P16233. Sequence length is 465 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Pancreatic triacylglycerol lipase shows approved-linked disease relevance led by obesity. 4 more disease programs remain visible in the same review block.
Start review with obesity because it currently carries approved-linked support. Linked drugs include CETILISTAT, ORLISTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL175247 | 8.8 | IC50 | 1.57 | Approved |
| CHEMBL470029 | 6.31 | IC50 | 490.0 | Preclinical |
| CHEMBL4173252 | 5.96 | IC50 | 1100.0 | Preclinical |
| CHEMBL4160519 | 5.9 | IC50 | 1250.0 | Preclinical |
| CHEMBL5416736 | 5.89 | Ki | 1288.0 | Preclinical |
| CHEMBL164 | 5.87 | IC50 | 1340.0 | Preclinical |
| CHEMBL50 | 5.82 | IC50 | 1530.0 | Clinical |
| CHEMBL4641560 | 5.79 | IC50 | 1630.0 | Preclinical |
| CHEMBL4164998 | 5.78 | IC50 | 1650.0 | Preclinical |
| CHEMBL5410259 | 5.78 | Ki | 1670.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 56 | 72 | 5.3 |
| assay format | 6 | 0 | — |
| subcellular format | 2 | 0 | — |
| cell-based format | 1 | 1 | 8.2 |