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Target Snapshot

CHEMBL1822 Target Snapshot

Inosine-5'-monophosphate dehydrogenase 1 · SINGLE PROTEIN · Homo sapiens

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184Compounds
29Assays
2Approved Drugs
200.0Activities
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Broader Open DB context

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Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Inosine-5'-monophosphate dehydrogenase 1 shows approved-linked disease relevance led by chronic hepatitis C virus infection. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P20839. Start with chronic hepatitis C virus infection, then reuse UniProt P20839 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with chronic hepatitis C virus infection, then reuse UniProt P20839 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
chronic hepatitis C virus infection

Inosine-5'-monophosphate dehydrogenase 1 shows approved-linked disease relevance led by chronic hepatitis C virus infection. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with chronic hepatitis C virus infection because it currently carries approved-linked support. Linked drugs include RIBAVIRIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Inosine-5'-monophosphate dehydrogenase 1 as ChEMBL target CHEMBL1822, mapped to UniProt P20839. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Inosine-5'-monophosphate dehydrogenase 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1822
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P20839
Inosine-5'-monophosphate dehydrogenase 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Inosine-5'-monophosphate dehydrogenase 1 is the right protein anchor across sources, using UniProt P20839 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why chronic hepatitis C virus infection is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
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Overview

Basic Information

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Preferred NameInosine-5'-monophosphate dehydrogenase 1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP20839
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelInosine-5'-monophosphate dehydrogenase 1
UniProt AccessionP20839
Component TypeProtein
Sequence Length514 aa

Inosine-5'-monophosphate dehydrogenase 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Inosine-5'-monophosphate dehydrogenase 1, mapped to UniProt P20839. Sequence length is 514 aa.

Mapped IDP20839
Review nameInosine-5'-monophosphate dehydrogenase 1
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Inosine-5'-monophosphate dehydrogenase 1 shows approved-linked disease relevance led by chronic hepatitis C virus infection. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
chronic hepatitis C virus infection
1 linked drug · 1 direct · 1 efficacy
Linked drugRIBAVIRIN
Approved-linked Approved
cirrhosis of liver
1 linked drug · 1 direct · 1 efficacy
Linked drugRIBAVIRIN
Approved-linked Approved
cirrhosis of liver
1 linked drug · 1 direct · 1 efficacy
Linked drugRIBAVIRIN
Approved-linked Approved
fibrosis
1 linked drug · 1 direct · 1 efficacy
Linked drugRIBAVIRIN
Approved-linked Approved
viral disease
1 linked drug · 1 direct · 1 efficacy
Linked drugRIBAVIRIN
Late clinical Phase III
COVID-19
2 linked drugs · 2 direct · 2 efficacy
Linked drugMERIMEPODIB
Linked drugRIBAVIRIN
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with chronic hepatitis C virus infection because it currently carries approved-linked support. Linked drugs include RIBAVIRIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasechronic hepatitis C virus infection
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC5055.0
KI144.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3098189 9.22 Ki 0.6 Preclinical
CHEMBL1683637 9.0 Ki 1.0 Preclinical
CHEMBL392203 9.0 Ki 1.0 Preclinical
CHEMBL3098184 8.52 Ki 3.0 Preclinical
CHEMBL1683640 8.3 Ki 5.0 Preclinical
CHEMBL3098187 8.25 Ki 5.6 Preclinical
CHEMBL409560 8.15 Ki 7.0 Preclinical
CHEMBL235533 8.0 Ki 10.0 Preclinical
CHEMBL1683638 7.89 Ki 13.0 Preclinical
CHEMBL3098188 7.89 Ki 13.0 Preclinical
Distribution

pChEMBL Value Distribution

22
5.0
23
5.5
36
6.0
20
6.5
43
7.0
15
7.5
4
8.0
1
8.5
3
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MYCOPHENOLIC ACID
CHEMBL866
Approved 2004
Properties Compare Identifier
Assay Landscape

Assay Landscape

29
Total Assays
164
Tested Compounds
1
Assay Types
Binding — 29 assays, 164 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 25 144 6.5
assay format 3 20 5.4
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine