Tumor necrosis factor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Tumor necrosis factor shows approved-linked disease relevance led by rheumatoid arthritis. 5 more disease programs remain visible in the same review block. 10 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P01375. Start with rheumatoid arthritis, then reuse UniProt P01375 as the stable protein anchor across project notes and exports.
Start with rheumatoid arthritis, then reuse UniProt P01375 as the stable protein anchor across project notes and exports.
Tumor necrosis factor shows approved-linked disease relevance led by rheumatoid arthritis. 5 more disease programs remain visible in the same review block. 10 linked drugs remain visible in the same block.
Start review with rheumatoid arthritis because it currently carries approved-linked support. Linked drugs include ABBV-3373, ADALIMUMAB, CERTOLIZUMAB PEGOL, ETANERCEPT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyTumor necrosis factor
Review this target as Tumor necrosis factor, mapped to UniProt P01375. Sequence length is 233 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tumor necrosis factor as ChEMBL target CHEMBL1825, mapped to UniProt P01375. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Tumor necrosis factor is the right protein anchor across sources, using UniProt P01375 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why rheumatoid arthritis is currently framed as approved-linked support. It currently carries 10 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Tumor necrosis factor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P01375 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tumor necrosis factor |
| UniProt Accession | P01375 |
| Component Type | Protein |
| Sequence Length | 233 aa |
Tumor necrosis factor
Review this target as Tumor necrosis factor, mapped to UniProt P01375. Sequence length is 233 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Tumor necrosis factor shows approved-linked disease relevance led by rheumatoid arthritis. 5 more disease programs remain visible in the same review block.
Start review with rheumatoid arthritis because it currently carries approved-linked support. Linked drugs include ABBV-3373, ADALIMUMAB, CERTOLIZUMAB PEGOL, ETANERCEPT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3640299 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL3642435 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL3640298 | 10.28 | Ki | 0.0521 | Preclinical |
| CHEMBL3640339 | 10.28 | Ki | 0.0524 | Preclinical |
| CHEMBL3640336 | 10.25 | Ki | 0.0556 | Preclinical |
| CHEMBL3642459 | 10.22 | Ki | 0.06 | Preclinical |
| CHEMBL3640352 | 10.2 | Ki | 0.0627 | Preclinical |
| CHEMBL3642501 | 10.2 | Ki | 0.063 | Preclinical |
| CHEMBL3640337 | 10.19 | Ki | 0.0651 | Preclinical |
| CHEMBL3642496 | 10.14 | Ki | 0.072 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 84 | 470 | 7.5 |
| assay format | 38 | 1,108 | 6.8 |
| cell-based format | 29 | 104 | 5.6 |
| tissue-based format | 8 | 2 | 6.1 |
| organism-based format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 23 | 223 | 5.3 |
| organism-based format | 3 | 0 | — |
| tissue-based format | 3 | 11 | 6.1 |
| cell-based format | 2 | 47 | 5.5 |