Histone deacetylase 3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Histone deacetylase 3 shows approved-linked disease relevance led by cancer. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt O15379. Start with cancer, then reuse UniProt O15379 as the stable protein anchor across project notes and exports.
Start with cancer, then reuse UniProt O15379 as the stable protein anchor across project notes and exports.
Histone deacetylase 3 shows approved-linked disease relevance led by cancer. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with cancer because it currently carries approved-linked support. Linked drugs include MOCETINOSTAT, VORINOSTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyHistone deacetylase 3
Review this target as Histone deacetylase 3, mapped to UniProt O15379. Sequence length is 428 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histone deacetylase 3 as ChEMBL target CHEMBL1829, mapped to UniProt O15379. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Histone deacetylase 3 is the right protein anchor across sources, using UniProt O15379 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why cancer is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Histone deacetylase 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O15379 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histone deacetylase 3 |
| UniProt Accession | O15379 |
| Component Type | Protein |
| Sequence Length | 428 aa |
Histone deacetylase 3
Review this target as Histone deacetylase 3, mapped to UniProt O15379. Sequence length is 428 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Histone deacetylase 3 shows approved-linked disease relevance led by cancer. 5 more disease programs remain visible in the same review block.
Start review with cancer because it currently carries approved-linked support. Linked drugs include MOCETINOSTAT, VORINOSTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5413269 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL4860000 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL4862152 | 10.1 | IC50 | 0.08 | Preclinical |
| CHEMBL4641682 | 10.06 | IC50 | 0.087 | Preclinical |
| CHEMBL4649205 | 10.03 | IC50 | 0.093 | Preclinical |
| CHEMBL483254 | 10.0 | Ki | 0.1 | Approved |
| CHEMBL4861467 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL4878197 | 9.89 | IC50 | 0.13 | Preclinical |
| CHEMBL99 | 9.85 | Ki | 0.14 | Preclinical |
| CHEMBL343448 | 9.82 | Ki | 0.15 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 568 | 2,056 | 6.7 |
| cell-based format | 158 | 452 | 6.7 |
| assay format | 25 | 63 | 6.3 |
| subcellular format | 4 | 34 | 6.5 |
| organism-based format | 1 | 2 | 8.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 6 | 6.8 |
| cell-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 7.3 |