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Target Snapshot

CHEMBL1839 Target Snapshot

Thyroid peroxidase · SINGLE PROTEIN · Homo sapiens

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69Compounds
12Assays
1Approved Drugs
99.0Activities
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Broader Open DB context

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Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Thyroid peroxidase shows approved-linked disease relevance led by Abnormality of the thyroid gland. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P07202. Start with Abnormality of the thyroid gland, then reuse UniProt P07202 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with Abnormality of the thyroid gland, then reuse UniProt P07202 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 3 linked drugs
Open source guide
Disease program
Abnormality of the thyroid gland

Thyroid peroxidase shows approved-linked disease relevance led by Abnormality of the thyroid gland. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.

Start review with Abnormality of the thyroid gland because it currently carries approved-linked support. Linked drugs include CARBIMAZOLE, METHIMAZOLE, PROPYLTHIOURACIL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 3 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Thyroid peroxidase as ChEMBL target CHEMBL1839, mapped to UniProt P07202. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Thyroid peroxidase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1839
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P07202
Thyroid peroxidase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Thyroid peroxidase is the right protein anchor across sources, using UniProt P07202 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why Abnormality of the thyroid gland is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameThyroid peroxidase
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP07202
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelThyroid peroxidase
UniProt AccessionP07202
Component TypeProtein
Sequence Length933 aa

Thyroid peroxidase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Thyroid peroxidase, mapped to UniProt P07202. Sequence length is 933 aa.

Mapped IDP07202
Review nameThyroid peroxidase
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Thyroid peroxidase shows approved-linked disease relevance led by Abnormality of the thyroid gland. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
Abnormality of the thyroid gland
3 linked drugs · 3 direct · 3 efficacy
Linked drugCARBIMAZOLE
Linked drugMETHIMAZOLE
Linked drugPROPYLTHIOURACIL
Approved-linked Approved
hyperthyroidism
2 linked drugs · 2 direct · 2 efficacy
Linked drugMETHIMAZOLE
Linked drugPROPYLTHIOURACIL
Late clinical Phase III
Graves disease
2 linked drugs · 2 direct · 2 efficacy
Linked drugMETHIMAZOLE
Linked drugPROPYLTHIOURACIL
Late clinical Phase III
Graves ophthalmopathy
2 linked drugs · 2 direct · 2 efficacy
Linked drugMETHIMAZOLE
Linked drugPROPYLTHIOURACIL
Late clinical Phase III
Thyrotoxicosis
2 linked drugs · 2 direct · 2 efficacy
Linked drugCARBIMAZOLE
Linked drugPROPYLTHIOURACIL
Clinical signal Phase II
dermatomyositis
1 linked drug · 1 direct · 1 efficacy
Linked drugMETHIMAZOLE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with Abnormality of the thyroid gland because it currently carries approved-linked support. Linked drugs include CARBIMAZOLE, METHIMAZOLE, PROPYLTHIOURACIL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseAbnormality of the thyroid gland
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5099.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5200638 6.23 IC50 590.0 Preclinical
CHEMBL4859908 6.19 IC50 640.0 Preclinical
CHEMBL4869433 6.16 IC50 700.0 Preclinical
CHEMBL4855931 6.15 IC50 710.0 Preclinical
CHEMBL5181350 6.11 IC50 770.0 Preclinical
CHEMBL5095218 6.05 IC50 890.0 Clinical
CHEMBL3633460 6.0 IC50 990.0 Preclinical
CHEMBL4853722 5.96 IC50 1100.0 Preclinical
CHEMBL4862053 5.96 IC50 1100.0 Preclinical
CHEMBL4863015 5.96 IC50 1100.0 Preclinical
Distribution

pChEMBL Value Distribution

27
5.0
18
5.5
7
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

12
Total Assays
72
Tested Compounds
1
Assay Types
Binding — 12 assays, 72 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 7 25 4.9
cell-based format 3 32 5.7
assay format 2 15 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine