Sodium channel protein type 1 subunit alpha · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P35498. Use UniProt P35498 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P35498 as the stable identity anchor, then attach disease evidence before program review.
Sodium channel protein type 1 subunit alpha
Review this target as Sodium channel protein type 1 subunit alpha, mapped to UniProt P35498. Sequence length is 2009 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sodium channel protein type 1 subunit alpha as ChEMBL target CHEMBL1845, mapped to UniProt P35498. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Sodium channel protein type 1 subunit alpha |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P35498 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sodium channel protein type 1 subunit alpha |
| UniProt Accession | P35498 |
| Component Type | Protein |
| Sequence Length | 2009 aa |
Sodium channel protein type 1 subunit alpha
Review this target as Sodium channel protein type 1 subunit alpha, mapped to UniProt P35498. Sequence length is 2009 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL501134 | 8.64 | IC50 | 2.3 | Preclinical |
| CHEMBL507974 | 8.39 | IC50 | 4.1 | Clinical |
| CHEMBL3662190 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL5082582 | 8.1 | EC50 | 7.9 | Preclinical |
| CHEMBL3657855 | 7.97 | IC50 | 10.6 | Preclinical |
| CHEMBL4293085 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL3318132 | 7.8 | IC50 | 16.0 | Preclinical |
| CHEMBL4276884 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL5884546 | 7.51 | IC50 | 31.0 | Preclinical |
| CHEMBL3617053 | 7.5 | IC50 | 32.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 58 | 151 | 5.6 |
| assay format | 19 | 715 | 5.0 |
| single protein format | 14 | 34 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 11 | 4 | 6.1 |
| assay format | 1 | 0 | — |