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Target Snapshot

CHEMBL1857 Target Snapshot

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI · SINGLE PROTEIN · Escherichia coli K-12

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181Compounds
56Assays
1Approved Drugs
198.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P0AEK4. Use UniProt P0AEK4 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P0AEK4 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Enoyl-[acyl-carrier-protein] reductase [NADH] FabI as ChEMBL target CHEMBL1857, mapped to UniProt P0AEK4. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
SINGLE PROTEIN · Escherichia coli K-12
As of 2026-09-13
ChEMBL target ID
CHEMBL1857
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P0AEK4
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Enoyl-[acyl-carrier-protein] reductase [NADH] FabI is the right protein anchor across sources, using UniProt P0AEK4 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameEnoyl-[acyl-carrier-protein] reductase [NADH] FabI
Target TypeSINGLE PROTEIN
OrganismEscherichia coli K-12
UniProtP0AEK4
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelEnoyl-[acyl-carrier-protein] reductase [NADH] FabI
UniProt AccessionP0AEK4
Component TypeProtein
Sequence Length262 aa

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Enoyl-[acyl-carrier-protein] reductase [NADH] FabI, mapped to UniProt P0AEK4. Sequence length is 262 aa.

Mapped IDP0AEK4
Review nameEnoyl-[acyl-carrier-protein] reductase [NADH] FabI
OrganismEscherichia coli K-12
Clinical Profile

Clinical Phase Distribution

1
Approved
3
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC50191.0
KI7.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL566647 9.4 IC50 0.4 Preclinical
CHEMBL148515 9.3 Ki 0.5 Preclinical
CHEMBL586043 9.15 IC50 0.7 Preclinical
CHEMBL149009 9.15 Ki 0.7 Preclinical
CHEMBL567711 8.74 IC50 1.8 Preclinical
CHEMBL566665 8.62 IC50 2.4 Preclinical
CHEMBL849 8.3 IC50 5.0 Approved
CHEMBL566043 8.15 IC50 7.0 Preclinical
CHEMBL148755 8.15 Ki 7.0 Preclinical
CHEMBL583197 8.05 IC50 9.0 Preclinical
Distribution

pChEMBL Value Distribution

30
5.0
9
5.5
21
6.0
13
6.5
5
7.0
10
7.5
4
8.0
2
8.5
4
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TRICLOSAN
CHEMBL849
Approved 1997
Properties Compare Identifier
Assay Landscape

Assay Landscape

56
Total Assays
118
Tested Compounds
1
Assay Types
Binding — 56 assays, 118 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 36 65 6.3
single protein format 20 53 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine