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Target Snapshot

CHEMBL1860 Target Snapshot

Thyroid hormone receptor alpha · SINGLE PROTEIN · Homo sapiens

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671Compounds
110Assays
8Approved Drugs
765.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P10827. Use UniProt P10827 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P10827 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Thyroid hormone receptor alpha as ChEMBL target CHEMBL1860, mapped to UniProt P10827. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Thyroid hormone receptor alpha
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1860
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P10827
Thyroid hormone receptor alpha
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Thyroid hormone receptor alpha is the right protein anchor across sources, using UniProt P10827 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameThyroid hormone receptor alpha
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP10827
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelThyroid hormone receptor alpha
UniProt AccessionP10827
Component TypeProtein
Sequence Length490 aa

Thyroid hormone receptor alpha

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Thyroid hormone receptor alpha, mapped to UniProt P10827. Sequence length is 490 aa.

Mapped IDP10827
Review nameThyroid hormone receptor alpha
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

8
Approved
3
Phase III
8
Phase II
Assay Mix

Activity Type Distribution

IC50426.0
KI113.0
EC50195.0
KD31.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL291053 10.39 IC50 0.04074 Clinical
CHEMBL1544 10.24 Kd 0.058 Approved
CHEMBL289343 10.0 IC50 0.1 Preclinical
CHEMBL41314 9.85 IC50 0.14 Preclinical
CHEMBL41632 9.85 IC50 0.14 Clinical
CHEMBL1544 9.66 Ki 0.22 Approved
CHEMBL1544 9.62 IC50 0.24 Approved
CHEMBL557 9.62 IC50 0.2399 Clinical
CHEMBL418432 9.52 EC50 0.3 Preclinical
CHEMBL3397337 9.46 Ki 0.35 Preclinical
Distribution

pChEMBL Value Distribution

70
5.0
88
5.5
77
6.0
74
6.5
62
7.0
47
7.5
34
8.0
31
8.5
15
9.0
12
9.5
pChEMBL
Approved Drugs

Approved Drugs

RESMETIROM
CHEMBL3261331
Approved 2024
Properties Compare Identifier
ROXADUSTAT
CHEMBL2338329
Approved 2021
Properties Compare Identifier
AMIODARONE
CHEMBL633
Approved 1985
Properties Compare Identifier
LEVOTHYROXINE
CHEMBL1624
Approved 1982
Properties Compare Identifier
LIOTHYRONINE
CHEMBL1544
Approved 1956
Properties Compare Identifier
Assay Landscape

Assay Landscape

110
Total Assays
450
Tested Compounds
3
Assay Types
Binding — 89 assays, 450 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 45 270 6.6
cell-based format 38 91 7.2
assay format 6 89 6.1
Functional — 19 assays, 33 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 15 9 7.5
assay format 4 24 6.4
ADME — 2 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 1 7.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine