Tyrosine-protein kinase ABL1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Tyrosine-protein kinase ABL1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 11 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P00519. Start with neoplasm, then reuse UniProt P00519 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt P00519 as the stable protein anchor across project notes and exports.
Tyrosine-protein kinase ABL1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 11 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include ASCIMINIB, AT-9283, AZD-0424, BOSUTINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyTyrosine-protein kinase ABL1
Review this target as Tyrosine-protein kinase ABL1, mapped to UniProt P00519. Sequence length is 1130 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tyrosine-protein kinase ABL1 as ChEMBL target CHEMBL1862, mapped to UniProt P00519. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Tyrosine-protein kinase ABL1 is the right protein anchor across sources, using UniProt P00519 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 11 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Tyrosine-protein kinase ABL1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P00519 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase ABL1 |
| UniProt Accession | P00519 |
| Component Type | Protein |
| Sequence Length | 1130 aa |
Tyrosine-protein kinase ABL1
Review this target as Tyrosine-protein kinase ABL1, mapped to UniProt P00519. Sequence length is 1130 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Tyrosine-protein kinase ABL1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include ASCIMINIB, AT-9283, AZD-0424, BOSUTINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2347725 | 10.82 | IC50 | 0.015 | Preclinical |
| CHEMBL5416410 | 10.8 | Kd | 0.016 | Approved |
| CHEMBL3689722 | 10.73 | Ki | 0.0186 | Preclinical |
| CHEMBL3689554 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL1221411 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL577269 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL3685056 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL3639840 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL3685101 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL3685180 | 10.7 | Ki | 0.02 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1,830 | 2,405 | 7.5 |
| assay format | 590 | 377 | 7.1 |
| cell-based format | 267 | 350 | 8.2 |
| subcellular format | 23 | 93 | 6.0 |
| protein format | 20 | 76 | 6.6 |
| cell membrane format | 1 | 3 | 4.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 7 | 3 | 7.5 |
| single protein format | 5 | 3 | 7.6 |
| assay format | 4 | 4 | 6.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 231 | 6.5 |
| cell-based format | 1 | 2 | 6.3 |