Ornithine decarboxylase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Ornithine decarboxylase shows approved-linked disease relevance led by Hirsutism. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P11926. Start with Hirsutism, then reuse UniProt P11926 as the stable protein anchor across project notes and exports.
Start with Hirsutism, then reuse UniProt P11926 as the stable protein anchor across project notes and exports.
Ornithine decarboxylase shows approved-linked disease relevance led by Hirsutism. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with Hirsutism because it currently carries approved-linked support. Linked drugs include EFLORNITHINE HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyOrnithine decarboxylase
Review this target as Ornithine decarboxylase, mapped to UniProt P11926. Sequence length is 461 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Ornithine decarboxylase as ChEMBL target CHEMBL1869, mapped to UniProt P11926. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Ornithine decarboxylase is the right protein anchor across sources, using UniProt P11926 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Hirsutism is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | Ornithine decarboxylase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P11926 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Ornithine decarboxylase |
| UniProt Accession | P11926 |
| Component Type | Protein |
| Sequence Length | 461 aa |
Ornithine decarboxylase
Review this target as Ornithine decarboxylase, mapped to UniProt P11926. Sequence length is 461 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Ornithine decarboxylase shows approved-linked disease relevance led by Hirsutism. 2 more disease programs remain visible in the same review block.
Start review with Hirsutism because it currently carries approved-linked support. Linked drugs include EFLORNITHINE HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2261742 | 6.3 | Kd | 500.0 | Preclinical |
| CHEMBL464609 | 5.96 | IC50 | 1100.0 | Preclinical |
| CHEMBL451703 | 5.68 | IC50 | 2100.0 | Preclinical |
| CHEMBL455606 | 5.66 | IC50 | 2200.0 | Preclinical |
| CHEMBL516860 | 5.64 | IC50 | 2300.0 | Preclinical |
| CHEMBL455604 | 5.58 | IC50 | 2600.0 | Preclinical |
| CHEMBL375582 | 5.47 | IC50 | 3400.0 | Preclinical |
| CHEMBL463206 | 5.44 | IC50 | 3600.0 | Preclinical |
| CHEMBL463011 | 5.41 | IC50 | 3900.0 | Preclinical |
| CHEMBL362378 | 5.33 | IC50 | 4700.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 12 | 13 | 5.4 |
| single protein format | 3 | 5 | 4.9 |