Neuronal acetylcholine receptor subunit alpha-4 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P43681. Use UniProt P43681 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P43681 as the stable identity anchor, then attach disease evidence before program review.
Neuronal acetylcholine receptor subunit alpha-4
Review this target as Neuronal acetylcholine receptor subunit alpha-4, mapped to UniProt P43681. Sequence length is 627 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neuronal acetylcholine receptor subunit alpha-4 as ChEMBL target CHEMBL1882, mapped to UniProt P43681. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Neuronal acetylcholine receptor subunit alpha-4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P43681 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neuronal acetylcholine receptor subunit alpha-4 |
| UniProt Accession | P43681 |
| Component Type | Protein |
| Sequence Length | 627 aa |
Neuronal acetylcholine receptor subunit alpha-4
Review this target as Neuronal acetylcholine receptor subunit alpha-4, mapped to UniProt P43681. Sequence length is 627 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2179534 | 8.82 | Ki | 1.5 | Preclinical |
| CHEMBL3676980 | 8.8 | Ki | 1.6 | Preclinical |
| CHEMBL2179547 | 8.77 | Ki | 1.7 | Preclinical |
| CHEMBL2179531 | 8.62 | Ki | 2.4 | Preclinical |
| CHEMBL2179540 | 8.34 | Ki | 4.6 | Preclinical |
| CHEMBL3676962 | 8.31 | Ki | 4.9 | Preclinical |
| CHEMBL2179544 | 8.28 | Ki | 5.2 | Preclinical |
| CHEMBL3676982 | 8.28 | Ki | 5.2 | Preclinical |
| CHEMBL2179543 | 8.14 | Ki | 7.3 | Preclinical |
| CHEMBL3676986 | 8.06 | Ki | 8.7 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 80 | 7.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 1 | 6.0 |