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Target Snapshot

CHEMBL1897 Target Snapshot

Squalene epoxidase ERG1 · SINGLE PROTEIN · Candida albicans

4Compounds
12Assays
1Approved Drugs
3.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q92206. Use UniProt Q92206 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q92206 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Squalene epoxidase ERG1 as ChEMBL target CHEMBL1897, mapped to UniProt Q92206. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Squalene epoxidase ERG1
SINGLE PROTEIN · Candida albicans
As of 2026-09-14
ChEMBL target ID
CHEMBL1897
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q92206
Squalene epoxidase ERG1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Squalene epoxidase ERG1 is the right protein anchor across sources, using UniProt Q92206 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSqualene epoxidase ERG1
UniProt AccessionQ92206
Component TypeProtein
Sequence Length496 aa

Squalene epoxidase ERG1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Squalene epoxidase ERG1, mapped to UniProt Q92206. Sequence length is 496 aa.

Mapped IDQ92206
Review nameSqualene epoxidase ERG1
OrganismCandida albicans
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC503.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL626 6.5 IC50 317.0 Approved
CHEMBL5206822 6.21 IC50 621.0 Preclinical
CHEMBL5180750 6.08 IC50 823.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
2
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

NAFTIFINE
CHEMBL626
Approved 1988
Assay Landscape

Assay Landscape

12
Total Assays
3
Tested Compounds
1
Assay Types
Binding — 12 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 12 3 6.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine