Sodium- and chloride-dependent GABA transporter 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Sodium- and chloride-dependent GABA transporter 1 shows approved-linked disease relevance led by Seizure. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P30531. Start with Seizure, then reuse UniProt P30531 as the stable protein anchor across project notes and exports.
Start with Seizure, then reuse UniProt P30531 as the stable protein anchor across project notes and exports.
Sodium- and chloride-dependent GABA transporter 1 shows approved-linked disease relevance led by Seizure. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with Seizure because it currently carries approved-linked support. Linked drugs include TIAGABINE HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxySodium- and chloride-dependent GABA transporter 1
Review this target as Sodium- and chloride-dependent GABA transporter 1, mapped to UniProt P30531. Sequence length is 599 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sodium- and chloride-dependent GABA transporter 1 as ChEMBL target CHEMBL1903, mapped to UniProt P30531. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Sodium- and chloride-dependent GABA transporter 1 is the right protein anchor across sources, using UniProt P30531 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Seizure is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | Sodium- and chloride-dependent GABA transporter 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P30531 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sodium- and chloride-dependent GABA transporter 1 |
| UniProt Accession | P30531 |
| Component Type | Protein |
| Sequence Length | 599 aa |
Sodium- and chloride-dependent GABA transporter 1
Review this target as Sodium- and chloride-dependent GABA transporter 1, mapped to UniProt P30531. Sequence length is 599 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Sodium- and chloride-dependent GABA transporter 1 shows approved-linked disease relevance led by Seizure. 2 more disease programs remain visible in the same review block.
Start review with Seizure because it currently carries approved-linked support. Linked drugs include TIAGABINE HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL277498 | 8.0 | IC50 | 10.1 | Preclinical |
| CHEMBL1641613 | 7.83 | Ki | 14.79 | Preclinical |
| CHEMBL1027 | 7.77 | Ki | 16.98 | Approved |
| CHEMBL1642396 | 7.74 | Ki | 18.2 | Preclinical |
| CHEMBL1642400 | 7.72 | Ki | 19.05 | Preclinical |
| CHEMBL1642378 | 7.69 | Ki | 20.42 | Preclinical |
| CHEMBL1642397 | 7.66 | Ki | 21.88 | Preclinical |
| CHEMBL1642376 | 7.54 | Ki | 28.84 | Preclinical |
| CHEMBL1642379 | 7.53 | Ki | 29.51 | Preclinical |
| CHEMBL1642384 | 7.47 | Ki | 33.88 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 43 | 73 | 6.4 |
| single protein format | 12 | 48 | 5.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 5 | 6.9 |