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Target Snapshot

CHEMBL1907588 Target Snapshot

Acetylcholine receptor; alpha1/beta1/delta/gamma · PROTEIN COMPLEX · Homo sapiens

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301Compounds
62Assays
3Approved Drugs
265.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P02708. Use UniProt P02708 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P02708 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Acetylcholine receptor; alpha1/beta1/delta/gamma as ChEMBL target CHEMBL1907588, mapped to UniProt P02708. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Acetylcholine receptor; alpha1/beta1/delta/gamma
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1907588
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P02708
Acetylcholine receptor subunit alpha
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Acetylcholine receptor; alpha1/beta1/delta/gamma is the right protein anchor across sources, using UniProt P02708 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameAcetylcholine receptor; alpha1/beta1/delta/gamma
Target TypePROTEIN COMPLEX
OrganismHomo sapiens
UniProtP02708
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAcetylcholine receptor subunit alpha
UniProt AccessionP02708
Component TypeProtein
Sequence Length457 aa

Acetylcholine receptor subunit alpha

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Acetylcholine receptor; alpha1/beta1/delta/gamma, mapped to UniProt P02708. ChEMBL maps the protein component as Acetylcholine receptor subunit alpha. Sequence length is 457 aa.

Mapped IDP02708
Review nameAcetylcholine receptor; alpha1/beta1/delta/gamma
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
4
Phase III
2
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50162.0
KI58.0
EC5045.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL6623 10.28 EC50 0.053 Preclinical
CHEMBL566050 8.82 IC50 1.5 Preclinical
CHEMBL569465 8.7 IC50 2.0 Preclinical
CHEMBL566208 8.57 IC50 2.7 Preclinical
CHEMBL566886 8.41 IC50 3.9 Preclinical
CHEMBL565844 8.24 IC50 5.7 Preclinical
CHEMBL592854 8.24 IC50 5.8 Preclinical
CHEMBL599846 8.19 IC50 6.5 Preclinical
CHEMBL566001 8.12 IC50 7.6 Preclinical
CHEMBL589250 8.04 IC50 9.2 Preclinical
Distribution

pChEMBL Value Distribution

32
5.0
6
5.5
6
6.0
4
6.5
6
7.0
17
7.5
8
8.0
3
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

62
Total Assays
92
Tested Compounds
2
Assay Types
Binding — 33 assays, 27 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 16 11 5.6
protein complex format 14 15 5.6
cell membrane format 2 1 5.4
tissue-based format 1 0 —
Functional — 29 assays, 92 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 25 91 5.9
assay format 4 1 4.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine