Neuronal acetylcholine receptor; alpha2/beta2 · PROTEIN COMPLEX · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P12389. Use UniProt P12389 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P12389 as the stable identity anchor, then attach disease evidence before program review.
Neuronal acetylcholine receptor subunit alpha-2
Review this target as Neuronal acetylcholine receptor; alpha2/beta2, mapped to UniProt P12389. ChEMBL maps the protein component as Neuronal acetylcholine receptor subunit alpha-2. Sequence length is 511 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neuronal acetylcholine receptor; alpha2/beta2 as ChEMBL target CHEMBL1907592, mapped to UniProt P12389. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Neuronal acetylcholine receptor; alpha2/beta2 is the right protein anchor across sources, using UniProt P12389 as the stable mapping.
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| Preferred Name | Neuronal acetylcholine receptor; alpha2/beta2 |
| Target Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
| UniProt | P12389 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neuronal acetylcholine receptor subunit alpha-2 |
| UniProt Accession | P12389 |
| Component Type | Protein |
| Sequence Length | 511 aa |
Neuronal acetylcholine receptor subunit alpha-2
Review this target as Neuronal acetylcholine receptor; alpha2/beta2, mapped to UniProt P12389. ChEMBL maps the protein component as Neuronal acetylcholine receptor subunit alpha-2. Sequence length is 511 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL6623 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL301901 | 10.89 | Ki | 0.013 | Preclinical |
| CHEMBL6623 | 10.7 | Kd | 0.02 | Preclinical |
| CHEMBL56817 | 10.55 | Ki | 0.028 | Preclinical |
| CHEMBL3086994 | 10.54 | Ki | 0.029 | Preclinical |
| CHEMBL55138 | 10.51 | Ki | 0.031 | Preclinical |
| CHEMBL197830 | 10.46 | Ki | 0.035 | Preclinical |
| CHEMBL291961 | 10.43 | Ki | 0.037 | Preclinical |
| CHEMBL2409631 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL372133 | 10.4 | Ki | 0.04 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 21 | 58 | 7.7 |
| protein complex format | 11 | 80 | 8.5 |
| assay format | 2 | 7 | 9.0 |
| cell membrane format | 1 | 11 | 7.7 |