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Target Snapshot

CHEMBL1908382 Target Snapshot

Serine/threonine-protein kinase PRP4 homolog · SINGLE PROTEIN · Homo sapiens

289Compounds
119Assays
4Approved Drugs
86.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q13523. Use UniProt Q13523 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q13523 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Serine/threonine-protein kinase PRP4 homolog as ChEMBL target CHEMBL1908382, mapped to UniProt Q13523. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Serine/threonine-protein kinase PRP4 homolog
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1908382
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q13523
Serine/threonine-protein kinase PRP4 homolog
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Serine/threonine-protein kinase PRP4 homolog is the right protein anchor across sources, using UniProt Q13523 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSerine/threonine-protein kinase PRP4 homolog
UniProt AccessionQ13523
Component TypeProtein
Sequence Length1007 aa

Serine/threonine-protein kinase PRP4 homolog

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Serine/threonine-protein kinase PRP4 homolog, mapped to UniProt Q13523. Sequence length is 1007 aa.

Mapped IDQ13523
Review nameSerine/threonine-protein kinase PRP4 homolog
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

4
Approved
3
Phase III
2
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC504.0
KI1.0
KD81.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL502835 8.08 Kd 8.4 Approved
CHEMBL608533 7.26 Kd 55.0 Approved
CHEMBL388978 6.66 Kd 220.0 Preclinical
CHEMBL1908397 6.57 Kd 270.0 Preclinical
CHEMBL535 6.41 Kd 390.0 Approved
CHEMBL1287853 6.41 Kd 390.0 Approved
CHEMBL603469 6.26 Kd 550.0 Clinical
CHEMBL522892 6.25 Kd 560.0 Clinical
CHEMBL1721885 5.89 Kd 1300.0 Clinical
CHEMBL5186861 5.89 Ki 1300.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
5
5.5
6
6.0
2
6.5
2
7.0
0
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

FEDRATINIB
CHEMBL1287853
Approved 2019
MIDOSTAURIN
CHEMBL608533
Approved 2017
NINTEDANIB
CHEMBL502835
Approved 2014
SUNITINIB
CHEMBL535
Approved 2006
Assay Landscape

Assay Landscape

119
Total Assays
16
Tested Compounds
1
Assay Types
Binding — 119 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 73 15 6.2
assay format 17 1 5.9
subcellular format 17 0
cell-based format 12 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine