Mitogen-activated protein kinase kinase kinase 12 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Mitogen-activated protein kinase kinase kinase 12 shows clinical signal disease relevance led by Parkinson disease. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q12852. Start with Parkinson disease, then reuse UniProt Q12852 as the stable protein anchor across project notes and exports.
Start with Parkinson disease, then reuse UniProt Q12852 as the stable protein anchor across project notes and exports.
Mitogen-activated protein kinase kinase kinase 12 shows clinical signal disease relevance led by Parkinson disease. 1 linked drug remains visible in the same block.
Start review with Parkinson disease because it currently carries clinical signal support. Linked drugs include CEP-1347. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMitogen-activated protein kinase kinase kinase 12
Review this target as Mitogen-activated protein kinase kinase kinase 12, mapped to UniProt Q12852. Sequence length is 859 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase kinase kinase 12 as ChEMBL target CHEMBL1908389, mapped to UniProt Q12852. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Mitogen-activated protein kinase kinase kinase 12 is the right protein anchor across sources, using UniProt Q12852 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Parkinson disease is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | Mitogen-activated protein kinase kinase kinase 12 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q12852 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase kinase kinase 12 |
| UniProt Accession | Q12852 |
| Component Type | Protein |
| Sequence Length | 859 aa |
Mitogen-activated protein kinase kinase kinase 12
Review this target as Mitogen-activated protein kinase kinase kinase 12, mapped to UniProt Q12852. Sequence length is 859 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Mitogen-activated protein kinase kinase kinase 12 shows clinical signal disease relevance led by Parkinson disease.
Start review with Parkinson disease because it currently carries clinical signal support. Linked drugs include CEP-1347. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3733088 | 10.22 | Ki | 0.06 | Preclinical |
| CHEMBL6043592 | 9.96 | Kd | 0.11 | Preclinical |
| CHEMBL5413922 | 9.92 | Kd | 0.12 | Preclinical |
| CHEMBL3355003 | 9.77 | Ki | 0.17 | Preclinical |
| CHEMBL3715238 | 9.77 | Ki | 0.17 | Preclinical |
| CHEMBL3716226 | 9.77 | Ki | 0.17 | Preclinical |
| CHEMBL5825489 | 9.77 | Ki | 0.17 | Preclinical |
| CHEMBL3393337 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL6057411 | 9.68 | Kd | 0.21 | Preclinical |
| CHEMBL6027116 | 9.62 | Kd | 0.24 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 59 | 892 | 7.5 |
| cell-based format | 16 | 170 | 7.5 |
| subcellular format | 4 | 0 | — |