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Target Snapshot

CHEMBL1910 Target Snapshot

Adenosine deaminase · SINGLE PROTEIN · Homo sapiens

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273Compounds
40Assays
2Approved Drugs
272.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Adenosine deaminase shows approved-linked disease relevance led by anemia. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P00813. Start with anemia, then reuse UniProt P00813 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with anemia, then reuse UniProt P00813 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
anemia

Adenosine deaminase shows approved-linked disease relevance led by anemia. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with anemia because it currently carries approved-linked support. Linked drugs include PENTOSTATIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Adenosine deaminase as ChEMBL target CHEMBL1910, mapped to UniProt P00813. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Adenosine deaminase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1910
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P00813
Adenosine deaminase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Adenosine deaminase is the right protein anchor across sources, using UniProt P00813 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why anemia is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameAdenosine deaminase
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP00813
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAdenosine deaminase
UniProt AccessionP00813
Component TypeProtein
Sequence Length363 aa

Adenosine deaminase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Adenosine deaminase, mapped to UniProt P00813. Sequence length is 363 aa.

Mapped IDP00813
Review nameAdenosine deaminase
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Adenosine deaminase shows approved-linked disease relevance led by anemia. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
anemia
1 linked drug · 1 direct · 1 efficacy
Linked drugPENTOSTATIN
Approved-linked Approved
cancer
1 linked drug · 1 direct · 1 efficacy
Linked drugPENTOSTATIN
Approved-linked Approved
hairy cell leukemia
1 linked drug · 1 direct · 1 efficacy
Linked drugPENTOSTATIN
Approved-linked Approved
neoplasm
1 linked drug · 1 direct · 1 efficacy
Linked drugPENTOSTATIN
Late clinical Phase III
chronic lymphocytic leukemia
1 linked drug · 1 direct · 1 efficacy
Linked drugPENTOSTATIN
Late clinical Phase III
graft versus host disease
1 linked drug · 1 direct · 1 efficacy
Linked drugPENTOSTATIN
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with anemia because it currently carries approved-linked support. Linked drugs include PENTOSTATIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseanemia
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC50193.0
KI78.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1651377 11.0 Ki 0.01 Preclinical
CHEMBL284483 11.0 Ki 0.01 Clinical
CHEMBL604966 11.0 Ki 0.01 Preclinical
CHEMBL1580 10.59 Ki 0.026 Approved
CHEMBL1651379 10.28 Ki 0.053 Preclinical
CHEMBL50378 9.4 Ki 0.4 Preclinical
CHEMBL5864154 9.4 IC50 0.4 Preclinical
CHEMBL5818178 9.3 IC50 0.5 Preclinical
CHEMBL5755688 9.22 IC50 0.6 Preclinical
CHEMBL6005828 9.22 IC50 0.6 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
5
5.5
9
6.0
6
6.5
27
7.0
71
7.5
69
8.0
36
8.5
14
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

AFAMELANOTIDE
CHEMBL441738
Approved 2014
Properties Compare Identifier
PENTOSTATIN
CHEMBL1580
Approved 1991
Properties Compare Identifier
Assay Landscape

Assay Landscape

40
Total Assays
243
Tested Compounds
2
Assay Types
Binding — 35 assays, 243 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 28 54 7.5
assay format 3 186 8.1
cell-free format 2 2 —
cell-based format 1 1 —
organism-based format 1 0 —
ADME — 5 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 0 —
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine