Succinate-semialdehyde dehydrogenase, mitochondrial · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Succinate-semialdehyde dehydrogenase, mitochondrial shows approved-linked disease relevance led by bipolar disorder. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P51649. Start with bipolar disorder, then reuse UniProt P51649 as the stable protein anchor across project notes and exports.
Start with bipolar disorder, then reuse UniProt P51649 as the stable protein anchor across project notes and exports.
Succinate-semialdehyde dehydrogenase, mitochondrial shows approved-linked disease relevance led by bipolar disorder. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.
Start review with bipolar disorder because it currently carries approved-linked support. Linked drugs include DIVALPROEX SODIUM, VALPROATE SODIUM, VALPROIC ACID. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxySuccinate-semialdehyde dehydrogenase, mitochondrial
Review this target as Succinate-semialdehyde dehydrogenase, mitochondrial, mapped to UniProt P51649. Sequence length is 535 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Succinate-semialdehyde dehydrogenase, mitochondrial as ChEMBL target CHEMBL1911, mapped to UniProt P51649. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Succinate-semialdehyde dehydrogenase, mitochondrial is the right protein anchor across sources, using UniProt P51649 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why bipolar disorder is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | Succinate-semialdehyde dehydrogenase, mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P51649 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Succinate-semialdehyde dehydrogenase, mitochondrial |
| UniProt Accession | P51649 |
| Component Type | Protein |
| Sequence Length | 535 aa |
Succinate-semialdehyde dehydrogenase, mitochondrial
Review this target as Succinate-semialdehyde dehydrogenase, mitochondrial, mapped to UniProt P51649. Sequence length is 535 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Succinate-semialdehyde dehydrogenase, mitochondrial shows approved-linked disease relevance led by bipolar disorder. 5 more disease programs remain visible in the same review block.
Start review with bipolar disorder because it currently carries approved-linked support. Linked drugs include DIVALPROEX SODIUM, VALPROATE SODIUM, VALPROIC ACID. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL378577 | 6.46 | IC50 | 350.0 | Preclinical |
| CHEMBL13883 | 4.81 | IC50 | 15600.0 | Preclinical |
| CHEMBL14193 | 4.61 | IC50 | 24700.0 | Preclinical |
| CHEMBL378361 | 4.48 | IC50 | 33100.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 5 | 7 | 5.1 |