Platelet-derived growth factor receptor beta · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Platelet-derived growth factor receptor beta shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 9 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P09619. Start with neoplasm, then reuse UniProt P09619 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt P09619 as the stable protein anchor across project notes and exports.
Platelet-derived growth factor receptor beta shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 9 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include CATEQUENTINIB, CM-082, DASATINIB ANHYDROUS, IMATINIB MESYLATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyPlatelet-derived growth factor receptor beta
Review this target as Platelet-derived growth factor receptor beta, mapped to UniProt P09619. Sequence length is 1106 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Platelet-derived growth factor receptor beta as ChEMBL target CHEMBL1913, mapped to UniProt P09619. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Platelet-derived growth factor receptor beta is the right protein anchor across sources, using UniProt P09619 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 9 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Platelet-derived growth factor receptor beta |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P09619 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Platelet-derived growth factor receptor beta |
| UniProt Accession | P09619 |
| Component Type | Protein |
| Sequence Length | 1106 aa |
Platelet-derived growth factor receptor beta
Review this target as Platelet-derived growth factor receptor beta, mapped to UniProt P09619. Sequence length is 1106 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Platelet-derived growth factor receptor beta shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include CATEQUENTINIB, CM-082, DASATINIB ANHYDROUS, IMATINIB MESYLATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL535 | 10.12 | Kd | 0.075 | Approved |
| CHEMBL3752910 | 10.05 | Kd | 0.089 | Preclinical |
| CHEMBL526507 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL495749 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL196363 | 9.9 | Ki | 0.1259 | Preclinical |
| CHEMBL5977738 | 9.85 | IC50 | 0.14 | Preclinical |
| CHEMBL495984 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL2023477 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL2023485 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL1336 | 9.59 | IC50 | 0.26 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 743 | 1,196 | 7.0 |
| cell-based format | 204 | 646 | 7.0 |
| assay format | 111 | 79 | 7.0 |
| subcellular format | 1 | 52 | 6.2 |
| tissue-based format | 1 | 8 | 5.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 8 | 173 | 6.5 |
| cell-based format | 3 | 29 | 6.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 3 | 6.9 |
| assay format | 3 | 8 | 5.7 |
| cell-based format | 1 | 0 | — |