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Target Snapshot

CHEMBL1920 Target Snapshot

Gamma-aminobutyric acid receptor subunit beta-2 · SINGLE PROTEIN · Homo sapiens

3Compounds
3Assays
1Approved Drugs
1.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P47870. Use UniProt P47870 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P47870 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Gamma-aminobutyric acid receptor subunit beta-2 as ChEMBL target CHEMBL1920, mapped to UniProt P47870. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Gamma-aminobutyric acid receptor subunit beta-2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1920
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P47870
Gamma-aminobutyric acid receptor subunit beta-2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Gamma-aminobutyric acid receptor subunit beta-2 is the right protein anchor across sources, using UniProt P47870 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGamma-aminobutyric acid receptor subunit beta-2
UniProt AccessionP47870
Component TypeProtein
Sequence Length512 aa

Gamma-aminobutyric acid receptor subunit beta-2

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Gamma-aminobutyric acid receptor subunit beta-2, mapped to UniProt P47870. Sequence length is 512 aa.

Mapped IDP47870
Review nameGamma-aminobutyric acid receptor subunit beta-2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL190461 6.89 IC50 130.0 Approved
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CANNABIDIOL
CHEMBL190461
Approved 2018
Assay Landscape

Assay Landscape

3
Total Assays
1
Tested Compounds
1
Assay Types
Binding — 3 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 1 6.9
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine