Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL1926497 Target Snapshot

NADPH oxidase 5 · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
46Compounds
10Assays
0Approved Drugs
62.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q96PH1. Use UniProt Q96PH1 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q96PH1 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NADPH oxidase 5 as ChEMBL target CHEMBL1926497, mapped to UniProt Q96PH1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NADPH oxidase 5
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1926497
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q96PH1
NADPH oxidase 5
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NADPH oxidase 5 is the right protein anchor across sources, using UniProt Q96PH1 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNADPH oxidase 5
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ96PH1
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNADPH oxidase 5
UniProt AccessionQ96PH1
Component TypeProtein
Sequence Length765 aa

NADPH oxidase 5

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NADPH oxidase 5, mapped to UniProt Q96PH1. Sequence length is 765 aa.

Mapped IDQ96PH1
Review nameNADPH oxidase 5
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC5043.0
KI18.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL397686 7.7 IC50 20.0 Preclinical
CHEMBL1927146 6.44 Ki 360.0 Preclinical
CHEMBL4303187 6.39 Ki 410.0 Clinical
CHEMBL1927147 6.38 Ki 414.0 Preclinical
CHEMBL1927150 6.32 Ki 475.0 Preclinical
CHEMBL1927160 6.31 Ki 490.0 Preclinical
CHEMBL1927157 6.26 Ki 543.0 Preclinical
CHEMBL5218591 6.24 IC50 570.0 Preclinical
CHEMBL5398181 6.24 IC50 570.0 Preclinical
CHEMBL1927145 6.23 Ki 590.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
4
5.5
19
6.0
0
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

10
Total Assays
17
Tested Compounds
2
Assay Types
Binding — 9 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 6 13 4.8
single protein format 3 3 6.3
Functional — 1 assays, 17 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 17 6.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine